S1PR3

S1PR3
Identifiers
Aliases	S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	OMIM: 601965; MGI: 1339365; HomoloGene: 3829; GeneCards: S1PR3; OMA:S1PR3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,005,155 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	51,576,833 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; decidua; ; cardiac muscle tissue of right atrium; ; ventricular zone; ; right ventricle; ; right coronary artery; ; left coronary artery; ; tail of epididymis; ; Descending thoracic aorta; ; superficial temporal artery;
	Top expressed in
	internal carotid artery; ; molar; ; left lung lobe; ; external carotid artery; ; dermis; ; epithelium of lens; ; fossa; ; body of femur; ; lumbar spinal ganglion; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; lipid binding; integrin binding; sphingosine-1-phosphate receptor activity; G protein-coupled receptor activity; protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	Notch signaling pathway; signal transduction; anatomical structure morphogenesis; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of establishment of endothelial barrier; positive regulation of cell population proliferation; sphingosine-1-phosphate receptor signaling pathway; regulation of interleukin-1 beta production; cytokine production; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	1903
	13610
	ENSG00000213694
	ENSMUSG00000067586
	Q99500
	Q9Z0U9
	NM_005226
	NM_010101
	NP_005217
	NP_034231
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.⁵

Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.⁵

Evolution

Paralogues to S1PR3 Gene

Source:⁶

References

GRCh38: Ensembl release 89: ENSG00000213694 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000067586 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3".
"GeneCards®: The Human Gene Database".

Further reading

Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 16–24. Bibcode:2000NYASA.905...16H. doi:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438. S2CID 19435541.
Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 54–60. Bibcode:2000NYASA.905...54S. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. S2CID 9257870.
Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing". Ann. N. Y. Acad. Sci. 905 (1): 142–58. Bibcode:2000NYASA.905..142W. doi:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450. S2CID 9789496.
Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355.
Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733. S2CID 26300053.
Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway". Blood. 93 (9): 2984–90. doi:10.1182/blood.V93.9.2984. PMID 10216094.
Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID 10537322.
Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146. S2CID 1126846.
An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor". Arch. Biochem. Biophys. 375 (1): 69–77. doi:10.1006/abbi.1999.1589. PMID 10683250.
Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. doi:10.1152/ajpcell.2000.278.3.C612. PMID 10712250. S2CID 10976499.
Song D, Li M, Zhang L, Zhang K, An Y, Feng M, Wang F, Yeh CT, Wang J, Guo F (2024). "Sphingosine-1-phosphate receptor 3 promotes neuronal apoptosis via the TNF-α/caspase-3 signaling pathway after acute intracerebral hemorrhage". Mol Cell Neurosci. 131 103979. doi:10.1016/j.mcn.2024.103979. PMID 39581391.
Kimura T, Watanabe T, Sato K, et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3". Biochem. J. 348 (1): 71–6. doi:10.1042/0264-6021:3480071. PMC 1221037. PMID 10794715.

External links

"Lysophospholipid Receptors: S₁P₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067586 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3".

[6] "GeneCards®: The Human Gene Database".

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