GPR12

GPR12
Identifiers
Aliases	GPR12, GPCR12, GPCR21, PPP1R84, G protein-coupled receptor 12
External IDs	OMIM: 600752; MGI: 101909; HomoloGene: 3868; GeneCards: GPR12; OMA:GPR12 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	26,760,786 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	146,522,049 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; nucleus accumbens; ; caudate nucleus; ; prefrontal cortex; ; putamen; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	perirhinal cortex; ; entorhinal cortex; ; CA3 field; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; hippocampus proper; ; Region I of hippocampus proper; ; dorsal striatum; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; phosphatidylcholine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; cellular calcium ion homeostasis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2835
	14738
	ENSG00000132975
	ENSMUSG00000041468
	P47775
	P35412
	NM_005288
NM_001010941; NM_008151; NM_001359055; NM_001359056; NM_001359057;
	NM_001359058
	NP_005279
NP_001010941; NP_032177; NP_001345984; NP_001345985; NP_001345986;
	NP_001345987
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.⁵⁶⁷

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.⁸

Ligands

Inverse agonists

Cannabidiol⁹

Evolution

Paralogues

Source:¹⁰

References

GRCh38: Ensembl release 89: ENSG00000132975 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041468 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (December 1993). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters. 336 (2): 317–22. doi:10.1016/0014-5793(93)80828-I. PMID 8262253. S2CID 31345248.
Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–9. doi:10.1006/geno.1995.1154. PMID 8530049.
"Entrez Gene: GPR12 G protein-coupled receptor 12".
Bjursell M, Gerdin AK, Jönsson M, Surve VV, Svensson L, Huang XF, et al. (September 2006). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–66. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
Brown KJ, Laun AS, Song ZH (November 2017). "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications. 493 (1): 451–454. doi:10.1016/j.bbrc.2017.09.001. PMC 5849771. PMID 28888984.
"GeneCards®: The Human Gene Database".

Ligands

Evolution

Paralogues

References

Further reading