LPAR3

LPAR3
Identifiers
Aliases	LPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs	OMIM: 605106; MGI: 1929469; HomoloGene: 8123; GeneCards: LPAR3; OMA:LPAR3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	84,893,206 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,991,941 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; mucosa of paranasal sinus; ; spinal ganglia; ; olfactory zone of nasal mucosa; ; trigeminal ganglion; ; atrium; ; right auricle of heart; ; myocardium; ; cardiac muscle tissue of right atrium;
	Top expressed in
	lumbar spinal ganglion; ; endocardial cushion; ; right kidney; ; membranous bone; ; Dermatocranium; ; maxilla; ; mandible; ; vestibular membrane of cochlear duct; ; atrioventricular junction; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; lysophosphatidic acid receptor activity; G-protein alpha-subunit binding; phospholipid binding; lipid binding;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; axon; plasma membrane;
Biological process	chemical synaptic transmission; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; bleb assembly; positive regulation of collateral sprouting; signal transduction; positive regulation of MAPK cascade; positive regulation of calcium ion transport; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23566
	65086
	ENSG00000171517
	ENSMUSG00000036832
	Q9UBY5
	Q9EQ31
	NM_012152
	NM_022983
	NP_036284
	NP_075359
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidic acid receptor 3 also known as LPA₃ is a protein in humans that is encoded by the LPAR3 gene.⁵⁶ LPA₃ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).⁷

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.⁵

Evolution

Paralogues

Source:⁸

References

GRCh38: Ensembl release 89: ENSG00000171517 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000036832 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3".
Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122.
Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
"GeneCards®: The Human Gene Database".

External links

"Lysophospholipid Receptors: LPA₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171517 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036832 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3".

[pmid10488122-6] Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122.

[Choi_2010-7] Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

[8] "GeneCards®: The Human Gene Database".

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