Article · Wikipedia archive · Last revised Jun 13, 2026

1D-LSD

1D-LSD, also known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-LSD or as SYN-L-229, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is believed to be a prodrug of LSD and replaced 1V-LSD in Germany after 1V-LSD became covered by the German NpSG law in 2022.

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Jun 13, 2026
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1D-LSD
Clinical data
Other names1-(1,2-Dimethylcyclobutane-1-carbonyl)-LSD; 1-(1,2-Dimethylcyclobutane-1-carbonyl)-N,N-diethyllysergamide; SYN-L-229
Routes of
administration		Oral1
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Duration of action6–8 hours1
Identifiers
  • (8β)-1-(1,2-Dimethylcyclobutane-1-carbonyl)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide
PubChem CID
Chemical and physical data
FormulaC27H35N3O2
Molar mass433.596 g·mol−1
3D model (JSmol)
  • [H][C@@]12CC3=CN(C(=O)C4(C)CCC4C)C4=C3C(=CC=C4)C1=C[C@H](CN2C)C(=O)N(CC)CC
  • InChI=1S/C27H35N3O2/c1-6-29(7-2)25(31)19-13-21-20-9-8-10-22-24(20)18(14-23(21)28(5)15-19)16-30(22)26(32)27(4)12-11-17(27)3/h8-10,13,16-17,19,23H,6-7,11-12,14-15H2,1-5H3/t17?,19-,23-,27?/m1/s1
  • Key:RNVFVHAKGPSAIU-ZRCBXKLVSA-N

1D-LSD, also known as 1-(1,2-dimethylcyclobutane-1-carbonyl)-LSD or as SYN-L-229, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).1 It is believed to be a prodrug of LSD and replaced 1V-LSD in Germany after 1V-LSD became covered by the German NpSG law in 2022.21

Use and effects

1D-LSD has a dose of 10 to 350 μg depending on the intended use, with blotter tabs typically containing 150 μg.1 It is said to be roughly comparable in potency to 1V-LSD.1 1D-LSD is said to have a much faster onset than 1V-LSD or LSD but to also have a shorter duration in comparison (6–8 hours and 10–12 hours, respectively).1

Interactions

Chemistry

Analogues

Analogues of 1D-LSD include ALD-52 (1A-LSD), 1P-LSD, 1S-LSD, 1DD-LSD, 1V-LSD, 1cP-LSD, and 1T-LSD, among others.

History

1D-LSD was encountered online as a novel designer drug in October 2022 after 1V-LSD was prohibited in Germany in September 2022.1

Society and culture

Austria

According to the current legal situation, 1D-LSD is neither explicitly mentioned in the Narcotic Drugs Ordinance nor in the Psychotropic Substances Ordinance (SV/PV), thus it is neither to be classified as a narcotic drug in the sense of the SV nor as a psychotropic substance in the sense of the PV.

Canada

1D-LSD is not a controlled substance in Canada as of 2025.3

Germany

Since the 14 June 2024 1D-LSD (and 1T-LSD) are covered by the German NpSG law.

United States

1D-LSD is not an explicitly controlled substance in the United States.4 However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

See also

References

References

  1. "1D-LSD". АИПСИН (in Russian). Retrieved 1 January 2026.
  2. "Stuttgart: LSD variant being sold in German vending machine due to legal loophole". Sky News (Video). Germany. 13 June 2024.
  3. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
  4. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
External links