Article · Wikipedia archive · Last revised Jun 29, 2026

1DD-LSD

1DD-LSD, also known as 1-dodecanoyl-LSD or as SYN-L-004, is an acylated derivative of lysergic acid diethylamide (LSD). In animal studies, it produces a weak head-twitch response but with 27x lower potency than LSD itself. It is being researched as a potential slow-onset, long lasting prodrug for LSD which is expected to have reduced psychoactive effects.

Last revised
Jun 29, 2026
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1DD-LSD
Clinical data
Other names1-Dodecanoyl-LSD; SYN-L-004
Routes of
administration		Oral
Drug classSerotonergic psychedelic; Hallucinogen
Identifiers
  • (6aR,9R)-N,N-diethyl-6-methyl-4-dodecanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChem CID
Chemical and physical data
FormulaC32H47N3O2
Molar mass505.747 g·mol−1
3D model (JSmol)
  • CCCCCCCCCCCC(=O)N1C=C2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)C4=C2C1=CC=C4
  • InChI=1S/C32H47N3O2/c1-5-8-9-10-11-12-13-14-15-19-30(36)35-23-24-21-29-27(26-17-16-18-28(35)31(24)26)20-25(22-33(29)4)32(37)34(6-2)7-3/h16-18,20,23,25,29H,5-15,19,21-22H2,1-4H3/t25-,29-/m1/s1
  • Key:CEPIQEJKLWHRTL-VAVYLYDRSA-N

1DD-LSD, also known as 1-dodecanoyl-LSD or as SYN-L-004, is an acylated derivative of lysergic acid diethylamide (LSD). In animal studies, it produces a weak head-twitch response but with 27x lower potency than LSD itself. It is being researched as a potential slow-onset, long lasting prodrug for LSD which is expected to have reduced psychoactive effects.12

Use and effects

Interactions

Chemistry

Analogues

Analogues of 1DD-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1H-LSD, and 1V-LSD, among others.

Society and culture

Canada

1DD-LSD is not a controlled substance in Canada as of 2025.3

United States

1DD-LSD is not an explicitly controlled substance in the United States.4 However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

See also

References

References

  1. Kavanagh PV, Westphal F, Pulver B, Elliott SP, Stratford A, Halberstadt AL, Brandt SD (April 2024). "Analytical and behavioral characterization of 1-dodecanoyl-LSD (1DD-LSD)". Drug Testing and Analysis. 17 (1): 101–109. doi:10.1002/dta.3691. PMC 11730435. PMID 38569566.
  2. WO 2024/028495, Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", published 8 February 2024, assigned to Synex Holdings BV 
  3. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
  4. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
External links