Article · Wikipedia archive · Last revised Jul 3, 2026

1cP-LSD

1cP-LSD, or 1-CPA-LSD, also known as 1-cyclopropanoyl-LSD or as Curie, is a psychedelic drug of the lysergamide family and an acylated derivative of lysergic acid diethylamide (LSD) which has been sold as a designer drug. It is a prodrug of LSD.

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Jul 3, 2026
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Wikipedia ↗
1cP-LSD
Clinical data
Other names1-CPA-LSD; 1-cyclopropanoyl-LSD; 1-(Cyclopropylmethanoyl)-LSD; 1cP; Curie
Routes of
administration		Oral
Drug classSerotonergic psychedelic; Hallucinogen
Legal status
Legal status
Pharmacokinetic data
Duration of action5–10 hours12
Identifiers
  • (6aR,9R)-N,N-diethyl-7-methyl-4-cyclopropylmethanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC24H29N3O2
Molar mass391.515 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)C1CC1)c4cccc2c34)N(C)C5
  • InChI=1S/C24H29N3O2/c1-4-26(5-2)23(28)17-11-19-18-7-6-8-20-22(18)16(12-21(19)25(3)13-17)14-27(20)24(29)15-9-10-15/h6-8,11,14-15,17,21H,4-5,9-10,12-13H2,1-3H3/t17-,21-/m1/s1
  • Key:RAFUPYYDHPFASC-DYESRHJHSA-N

1cP-LSD, or 1-CPA-LSD, also known as 1-cyclopropanoyl-LSD or as Curie, is a psychedelic drug of the lysergamide family and an acylated derivative of lysergic acid diethylamide (LSD) which has been sold as a designer drug.3451 It is a prodrug of LSD.3

Use and effects

1cP-LSD has been used in the form of blotter tabs containing 100 μg 1cP-LSD free base and pellets containing 150 μg 1cP-LSD hemitartrate.3 Its dose is said to be 100 to 200 μg and it has comparable potency to 1P-LSD and 1B-LSD.12 Its duration has been said to be 5 to 10 hours.12

Interactions

Pharmacology

Pharmacodynamics

1cP-LSD is a prodrug of LSD.3 It has been found to produce psychedelic-like effects, specifically the head-twitch response, in rodents with similar potency as 1P-LSD.3

Chemistry

Analogues

Related compounds include 1B-LSD, 1DD-LSD, 1P-LSD, 1V-LSD, ALD-52 (1A-LSD), 1cP-AL-LAD, AL-LAD, ETH-LAD, 1P-ETH-LAD, PRO-LAD, LSM-775, and LSZ, among others.

Society and culture

1cP-LSD on blotter paper. source ↗

Canada

1cP-LSD is not a controlled substance in Canada as of 2025.6

Sweden

Sweden's public health agency suggested classifying 1cP-LSD as a dangerous substance on 18 December 2019 and later classified it as such on 22 April 2021.78

United States

1cP-LSD is not an explicitly controlled substance in the United States.9 However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

Research

1cP-LSD has been investigated as a potential treatment for anxiety in dogs and cats.101112

See also

See also

References

References

  1. "1cP-LSD". АИПСИН (in Russian). Retrieved 1 January 2026.
  2. "1cP-LSD". АИПСИН (in Russian). Retrieved 1 January 2026.
  3. Brandt SD, Kavanagh PV, Westphal F, Stratford A, Odland AU, Klein AK, et al. (June 2020). "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis. 12 (6): 812–826. doi:10.1002/dta.2789. PMC 9191646. PMID 32180350.
  4. Tanaka R, Kawamura M, Hakamatsuka T, Kikura-Hanajiri R (2020). "[Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet]". Yakugaku Zasshi. 140 (11): 1405–1413. doi:10.1248/yakushi.20-00124. PMID 33132277.
  5. Vincenti F, Gregori A, Flammini M, Di Rosa F, Salomone A (September 2021). "Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic". Forensic Science International. 326 110904. doi:10.1016/j.forsciint.2021.110904. PMC 8411784. PMID 34371393.
  6. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
  7. "Förordning (1999:58) om förbud mot vissa hälsofarliga varor".
  8. "Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara" [Twenty-three substances are proposed to be classified as drugs or dangerous goods] (in Swedish). Folkhälsomyndigheten. December 18, 2019. Archived from the original on November 24, 2022. Retrieved May 28, 2020.
  9. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  10. Hernández-Álvarez E, Borkel LF, Rojas-Hernández J, Quintana-Hernández DJ, García-Serrano I, Fernández-Borkel T, et al. (July 2025). "Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study". Veterinary Medicine and Science. 11 (4) e70486. doi:10.1002/vms3.70486. PMC 12244264. PMID 40638522.
  11. Hernández-Álvarez E, Rojas-Hernández J, Borkel LF, Quintana-Hernández DJ, Fernández-Borkel T, Henríquez-Hernández LA (September 2025). "Preliminary Findings on Low-Dose 1cp-LSD for Canine Anxiety: Exploring the Role of Owner Neuroticism and Psychopathology". Veterinary Sciences. 12 (9): 872. doi:10.3390/vetsci12090872. PMC 12474181. PMID 41012797.
  12. Hernández-Álvarez E, Canino-Quijada C, Roiz S, Luzardo OP, Henríquez-Hernández LA (January 2026). "Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention". Vet Sci. 13 (1). doi:10.3390/vetsci13010096. PMC 12846581. PMID 41600753.
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