Article · Wikipedia archive · Last revised Jun 25, 2026

1V-LSD

1V-LSD, also known as 1-valeryl-LSD or by the nickname Valerie, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is an analogue of LSD and is thought to act as a prodrug of LSD. The drug has been encountered as a novel designer recreational drug.

Last revised
Jun 25, 2026
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1V-LSD
Clinical data
Other names1-Valeryl-LSD; 1-Valeroyl-LSD; 1-Pentanoyl-LSD; Valerie; 1-Valeryl-N,N-diethyllysergamide
Routes of
administration		Oral1
Drug classSerotonergic psychedelic; Hallucinogen
Legal status
Legal status
  • AU: S8 (Controlled drug)
  • CA: Unscheduled
  • DE: NpSG (Industrial and scientific use only)
  • UK: Under Psychoactive Substances Act
  • US: Unscheduled (when wasn't sold for human consumption)
  • UN: Unscheduled
Pharmacokinetic data
Duration of action6–8 hours (reportedly)23
Identifiers
  • (6aR,9R)-N,N-Diethyl-7-methyl-4-pentanoyl-4,,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H33N3O2
Molar mass407.558 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)CCCC)c4cccc2c34)N(C)C5
  • InChI=1S/C25H33N3O2/c1-5-8-12-23(29)28-16-17-14-22-20(19-10-9-11-21(28)24(17)19)13-18(15-26(22)4)25(30)27(6-2)7-3/h9-11,13,16,18,22H,5-8,12,14-15H2,1-4H3/t18-,22-/m1/s1
  • Key:GIIBVGJWUZNECE-XMSQKQJNSA-N

1V-LSD, also known as 1-valeryl-LSD or by the nickname Valerie, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).412 It is an analogue of LSD and is thought to act as a prodrug of LSD.42 The drug has been encountered as a novel designer recreational drug.451

Use and effects

1V-LSD has been sold in the form of blotter containing 150 μg per tab.1 Its effects are said to be comparable to 100 to 120 μg 1P-LSD or 1cP-LSD, but with a longer duration.1 On the other hand, other sources report that 1V-LSD has a shorter duration than LSD of 6 to 8 hours.23

Interactions

Pharmacology

Pharmacodynamics

As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act directly as a weak partial agonist at the serotonin 5-HT2A receptor.4

A head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.6

Chemistry

Synthesis

1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.7

Detection

Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules.8 However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.910

Analogues

Related compounds include 1B-LSD, 1cP-LSD, 1D-LSD, 1P-LSD, and AL-LAD, among others.

History

1V-LSD was first described in the scientific literature by 2022.54

Society and culture

1v-LSD strip blotters. source ↗

Canada

1V-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.11

Germany

An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.12 The law was amended in March 2023, now banning 1V-LSD.

South Korea

1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.13

Sweden

Since 2 March 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.

United States

1V-LSD is not an explicitly controlled substance in the United States.14 However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.15

See also

See also

References

References

  1. "1V-LSD". АИПСИН (in Russian). Retrieved 1 January 2026.
  2. Niesporek T (17 August 2022). Der Hype um legales LSD in Deutschland: Wie das Verbot umgangen wird [The hype surrounding legal LSD in Germany: How the ban is circumvented] (in German). VICE auf Deutsch. Event occurs at 2:10–8:12, 20:05–20:41. Retrieved 29 September 2025 – via YouTube.
  3. Niesporek T (17 August 2022). "Wir haben den Erfinder von legalem LSD getroffen" [We met the inventor of legal LSD]. VICE. Archived from the original on 29 September 2025. Retrieved 29 September 2025.
  4. Brandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, et al. (November 2021). "Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD)". Drug Testing and Analysis. 14 (4): 733–740. doi:10.1002/dta.3205. PMC 9191648. PMID 34837347.
  5. Tanaka R, Kawamura M, Mizutani S, Kikura-Hanajiri R (2022). "Analyses of LSD analogs in illegal products: The identification of 1cP-AL-LAD, 1cP-MIPLA and 1V-LSD". Toxicologie Analytique et Clinique. 34 (3) S171. doi:10.1016/j.toxac.2022.06.295.
  6. Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, et al. (August 2020). "Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD)". Neuropharmacology. 172 107856. doi:10.1016/j.neuropharm.2019.107856. PMC 9191647. PMID 31756337.
  7. Umehara A, Ueda H, Tokuyama H (November 2016). "Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O". The Journal of Organic Chemistry. 81 (22): 11444–11453. doi:10.1021/acs.joc.6b02097. PMID 27767302.
  8. De Faubert Maunder MJ (August 1974). "A field test for hallucinogens: further improvements". The Journal of Pharmacy and Pharmacology. 26 (8): 637–638. doi:10.1111/j.2042-7158.1974.tb10677.x. PMID 4155730. S2CID 97915487.
  9. "REACTIONS 1V-LSD". PRO Test. 16 July 2021.
  10. "1V-LSD reaction with the ehrlich reagent". PRO Test. 16 July 2021.
  11. "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  12. "Gesetzespanne: Gefährliche LSD-Derivate plötzlich legal".
  13. Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily. Korea Biomedical Review, 5 July 2022
  14. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
  15. 21 U.S. Code § 813 - Treatment of controlled substance analogues
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