Article · Wikipedia archive · Last revised Jul 4, 2026

1T-LSD

1T-LSD, also known as 1-(thiophene-2-carbonyl)-LSD or as SYN-L-021, is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug. It was first identified in Japan in 2023 on blotter paper misrepresented as containing 1D-LSD, but which on analysis was determined to contain 1T-LSD instead. It was also detected in Germany around the same time.

Last revised
Jul 4, 2026
Read time
≈ 1 min
Length
309 w
Citations
8
Source
Wikipedia ↗
1T-LSD
Clinical data
Other names1-(Thiophene-2-carbonyl)-LSD; SYN-L-021
Routes of
administration		Oral
Drug classSerotonergic psychedelic; Hallucinogen
Identifiers
  • (6aR,9R)-N,N-diethyl-7-methyl-4-(thiophen-2-yl)methanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC25H27N3O2S
Molar mass433.57 g·mol−1
3D model (JSmol)
  • O=C(n1cc2C[C@@H]3C(=C[C@H](CN3C)C(=O)N(CC)CC)c3cccc1c32)c1cccs1

1T-LSD, also known as 1-(thiophene-2-carbonyl)-LSD or as SYN-L-021, is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug.12 It was first identified in Japan in 2023 on blotter paper misrepresented as containing 1D-LSD, but which on analysis was determined to contain 1T-LSD instead.3 It was also detected in Germany around the same time.4

Use and effects

A 150 μg dose of 1T-LSD is said to be equivalent to 100 μg LSD.2 Doses of 87 to 100 μg 1T-LSD have been encountered in blotter tabs.1

Interactions

Chemistry

Analogues

Analogues of 1T-LSD include ALD-52 (1A-LSD), 1P-LSD, 1B-LSD, 1V-LSD, 1DD-LSD, and 1T-AL-LAD, among others.

Society and culture

Canada

1T-LSD is not a controlled substance in Canada as of 2025.5

United States

1T-LSD is not an explicitly controlled substance in the United States.6 However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

See also

References

References

  1. "1T-LSD". АИПСИН (in Russian). 21 August 2023. Retrieved 1 January 2026.
  2. "1T-LSD". АИПСИН (in Russian). Retrieved 1 January 2026.
  3. Okada Y, Ueno K, Nishiwaki N, Nishimura T, Segawa H, Yamamuro T, et al. (July 2023). "Identification of 1-(thiophene-2-carbonyl)-LSD from blotter paper falsely labeled "1D-LSD"". Forensic Toxicology. 42 (1): 93–101. doi:10.1007/s11419-023-00668-8. PMID 37421500. S2CID 259374662.
  4. "New psychoactive substances - the current situation in Europe" (PDF). European Drug Report. European Union Drugs Agency (EUDA). 2024.
  5. "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
  6. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
External links