TSEN34

TSEN34
Identifiers
Aliases	TSEN34, LENG5, PCH2C, SEN34, SEN34L, tRNA splicing endonuclease subunit 34
External IDs	OMIM: 608754; MGI: 1913328; HomoloGene: 44182; GeneCards: TSEN34; OMA:TSEN34 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,194,536 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,704,023 bp
RNA expression pattern
	Top expressed in
	blood; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; gonad; ; mucosa of transverse colon; ; right ovary; ; right uterine tube; ; left ovary;
	Top expressed in
	mesencephalon; ; neural tube; ; yolk sac; ; epiblast; ; placenta; ; rhombencephalon; ; ventricular zone; ; stomach; ; lip; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA-intron endonuclease activity; lyase activity; nucleic acid binding; nuclease activity;
Cellular component	nucleolus; nucleus; tRNA-intron endonuclease complex; nucleoplasm;
Biological process	mRNA processing; tRNA-type intron splice site recognition and cleavage; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA splicing, via endonucleolytic cleavage and ligation; RNA phosphodiester bond hydrolysis; tRNA processing; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	79042
	66078
ENSG00000278622; ENSG00000274129; ENSG00000274796; ENSG00000278712; ENSG00000275165;
	ENSG00000278605; ENSG00000273896; ENSG00000274078; ENSG00000274672; ENSG00000170892
	ENSMUSG00000035585
	Q9BSV6
	Q8BMZ5
	NM_001077446; NM_001282332; NM_001282333; NM_024075; NM_001386740
	NM_001164204; NM_001164205; NM_024168
	NP_001070914; NP_001269261; NP_001269262; NP_076980
	NP_001157676; NP_001157677; NP_077130
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA-splicing endonuclease subunit Sen34 is an enzyme that in humans is encoded by the TSEN34 gene.⁵⁶⁷

tRNA splicing is a fundamental process required for cell growth and division. SEN34 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]⁷

Interactions

TSEN34 has been shown to interact with TSEN2.⁶

References

ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 GRCh38: Ensembl release 89: ENSG00000278622, ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035585 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
"Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".

External links

GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4

[refGRCh38Ensembl-1] ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 GRCh38: Ensembl release 89: ENSG00000278622, ENSG00000274129, ENSG00000274796, ENSG00000278712, ENSG00000275165, ENSG00000278605, ENSG00000273896, ENSG00000274078, ENSG00000274672, ENSG00000170892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035585 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10941842-5] Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.

[pmid15109492-6] Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.

[entrez-7] "Entrez Gene: TSEN34 tRNA splicing endonuclease 34 homolog (S. cerevisiae)".

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Interactions

References

Further reading

External links