TSEN2

TSEN2
Identifiers
Aliases	TSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs	OMIM: 608753; MGI: 2141599; HomoloGene: 41622; GeneCards: TSEN2; OMA:TSEN2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	12,541,549 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	115,555,589 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; mucosa of transverse colon; ; gonad; ; ventricular zone; ; testicle; ; gastrocnemius muscle; ; body of pancreas; ; cerebellar hemisphere; ; right uterine tube; ; muscle of thigh;
	Top expressed in
	Rostral migratory stream; ; yolk sac; ; epiblast; ; primitive streak; ; interventricular septum; ; hand; ; superior cervical ganglion; ; otolith organ; ; embryo; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	tRNA-intron endonuclease activity; protein binding; lyase activity; nucleic acid binding; nuclease activity;
Cellular component	centrosome; nucleolus; nucleus; tRNA-intron endonuclease complex; nucleoplasm; cytosol;
Biological process	mRNA processing; tRNA-type intron splice site recognition and cleavage; RNA phosphodiester bond hydrolysis, endonucleolytic; tRNA splicing, via endonucleolytic cleavage and ligation; RNA phosphodiester bond hydrolysis; tRNA processing; nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	80746
	381802
	ENSG00000154743
	ENSMUSG00000042389
	Q8NCE0
	Q6P7W5
NM_001145392; NM_001145393; NM_001145394; NM_001145395; NM_025265;
	NM_001321277; NM_001321278; NM_001321279
	NM_199033
NP_001138864; NP_001138865; NP_001138866; NP_001308206; NP_001308207;
	NP_001308208; NP_079541
	NP_950198
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.⁵⁶

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]⁶

Interactions

TSEN2 has been shown to interact with TSEN34⁵ and TSEN15.⁵

References

GRCh38: Ensembl release 89: ENSG00000154743 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042389 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.
"Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

External links

GeneReviews/NCBI/NIH/UW entry on Pontocerebellar Hypoplasia Type 2 and Type 4

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154743 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042389 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15109492-5] Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. S2CID 16049289.

[entrez-6] "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)".

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