SCAND1

SCAND1
Identifiers
Aliases	SCAND1, RAZ1, SDP1, SCAN domain containing 1
External IDs	OMIM: 610416; MGI: 1343132; HomoloGene: 10642; GeneCards: SCAND1; OMA:SCAND1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,959,472 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	156,154,667 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; anterior pituitary; ; right lobe of liver; ; apex of heart; ; right uterine tube; ; gastric mucosa;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; seminiferous tubule; ; yolk sac; ; muscle of thigh; ; medial ganglionic eminence; ; calvaria; ; internal carotid artery; ; right kidney; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; transcription coactivator activity; protein binding; identical protein binding; DNA binding;
Cellular component	nucleus;
Biological process	regulation of transcription, DNA-templated; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	51282
	19018
	ENSG00000171222
	ENSMUSG00000046229
	P57086
	Q2M4I6
	NM_033630; NM_016558; NM_001385710
	NM_020255
	NP_057642; NP_361012
	NP_064651
	Wikidata
View/Edit Human	View/Edit Mouse

SCAN domain-containing protein 1 is a protein that in humans is encoded by the SCAND1 gene.⁵⁶⁷⁸

Function

The SCAN domain is a highly conserved, leucine-rich motif of approximately 60 amino acids originally found within a subfamily of zinc finger proteins. This gene belongs to a family of genes that encode an isolated SCAN domain, but no zinc finger motif. Functional studies have established that the SCAN box is a protein interaction domain that mediates both hetero- and homoprotein associations, and maybe involved in regulation of transcriptional activity. Two transcript variants with different 5' UTRs, but encoding the same protein, have been described for this gene.⁸

Interactions

SCAND1 has been shown to interact with MZF1.⁵

References

GRCh38: Ensembl release 89: ENSG00000171222 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000046229 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry. 275 (17): 12857–67. doi:10.1074/jbc.275.17.12857. PMID 10777584.
Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.
Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.
"Entrez Gene: SCAND1 SCAN domain containing 1".

Further reading

Williams AJ, Blacklow SC, Collins T (Dec 1999). "The zinc finger-associated SCAN box is a conserved oligomerization domain". Molecular and Cellular Biology. 19 (12): 8526–35. doi:10.1128/mcb.19.12.8526. PMC 84969. PMID 10567577.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Sander TL, Morris JF (Aug 2002). "Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization". Gene. 296 (1–2): 53–64. doi:10.1016/S0378-1119(02)00792-8. PMID 12383503.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Carneiro FR, Silva TC, Alves AC, Haline-Vaz T, Gozzo FC, Zanchin NI (Apr 2006). "Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1". Biochemical and Biophysical Research Communications. 343 (1): 260–8. doi:10.1016/j.bbrc.2006.02.140. PMID 16540086.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171222 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046229 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10777584-5] Sander TL, Haas AL, Peterson MJ, Morris JF (Apr 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". The Journal of Biological Chemistry. 275 (17): 12857–67. doi:10.1074/jbc.275.17.12857. PMID 10777584.

[pmid10747874-6] Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S (Jun 2000). "The SCAN domain mediates selective oligomerization". The Journal of Biological Chemistry. 275 (22): 17173–9. doi:10.1074/jbc.M000119200. PMID 10747874.

[pmid12444922-7] Babb R, Bowen BR (Mar 2003). "SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain". The Biochemical Journal. 370 (Pt 2): 719–27. doi:10.1042/BJ20021378. PMC 1223195. PMID 12444922.

[entrez-8] "Entrez Gene: SCAND1 SCAN domain containing 1".

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