MZF1

MZF1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2FI2
Identifiers
Aliases	MZF1, MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6, myeloid zinc finger 1
External IDs	OMIM: 194550; MGI: 107457; HomoloGene: 9633; GeneCards: MZF1; OMA:MZF1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	58,573,575 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	12,788,691 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; right uterine tube; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; pituitary gland; ; left lobe of thyroid gland; ; anterior pituitary; ; right adrenal gland; ; right adrenal cortex; ; left ovary;
	Top expressed in
	male urethra; ; superior frontal gyrus; ; primary visual cortex; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; spermatocyte; ; granulocyte; ; tail of embryo; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; DNA binding; protein binding; nucleic acid binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7593
	109889
	ENSG00000099326
	ENSMUSG00000030380
	P28698
	n/a
	NM_001267033; NM_003422; NM_198055
	NM_001290452; NM_001290453; NM_145819; NM_001382820; NM_016793
	NP_001253962; NP_003413; NP_932172
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.⁵⁶

Interactions

MZF1 has been shown to interact with SCAND1.⁷ In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1.⁸ The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.⁹

References

GRCh38: Ensembl release 89: ENSG00000099326 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030380 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. doi:10.1016/S0021-9258(18)98664-3. PMID 1860835.
"Entrez Gene: MZF1 myeloid zinc finger 1".
Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. Bibcode:2014BBRC..451..137P. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.
Piszczatowski RT (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi:10.1002/jcp.25021. PMID 25899830. S2CID 6888015.

Further reading

Bavisotto L, Kaushansky K, Lin N, Hromas R (1991). "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro". J. Exp. Med. 174 (5): 1097–1101. doi:10.1084/jem.174.5.1097. PMC 2119006. PMID 1719120.
Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
Peterson MJ, Morris JF (2000). "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein". Gene. 254 (1–2): 105–118. doi:10.1016/S0378-1119(00)00281-X. PMID 10974541.
Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781. PMID 15453830.
Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells. 18 (2): 157–62. doi:10.1016/S1016-8478(23)13096-2. PMID 15528990.
Le Mée S, Fromigué O, Marie PJ (2005). "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts". Exp. Cell Res. 302 (1): 129–142. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–608. Bibcode:2005FEBSL.579..604I. doi:10.1016/j.febslet.2004.12.030. PMID 15670815. S2CID 30914046.
Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY (2006). "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells". Biochem. Biophys. Res. Commun. 339 (1): 217–225. Bibcode:2006BBRC..339..217H. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF (2006). "Structure of the SCAN domain from the tumor suppressor protein MZF1". J. Mol. Biol. 363 (1): 137–147. doi:10.1016/j.jmb.2006.07.063. PMC 1941711. PMID 16950398.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099326 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030380 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1860835-5] Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. doi:10.1016/S0021-9258(18)98664-3. PMID 1860835.

[entrez-6] "Entrez Gene: MZF1 myeloid zinc finger 1".

[pmid10777584-7] Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.

[pmid25065746-8] Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. Bibcode:2014BBRC..451..137P. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.

[9] Piszczatowski RT (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi:10.1002/jcp.25021. PMID 25899830. S2CID 6888015.

1

2

3

4

5

6

7

8

9