Article · Wikipedia archive · Last revised Jun 30, 2026

EMDT

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor. Its affinities for many other targets have also been reported. EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885. Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.

Last revised
Jun 30, 2026
Read time
≈ 1 min
Length
274 w
Citations
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Source
Wikipedia ↗
EMDT
Clinical data
Other names2-Ethyl-5-methoxy-N,N-dimethyltryptamine; 2-Ethyl-5-MeO-DMT; 2-Et-5-MeO-DMT
ATC code
  • none
Identifiers
  • 2-(2-ethyl-5-methoxy-1H-indol-3-yl)-N,N-dimethylethanamine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H22N2O
Molar mass246.354 g·mol−1
3D model (JSmol)
  • CCc2[nH]c1ccc(OC)cc1c2CCN(C)C
  • InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3 ☒N
  • Key:ZEYRDXUWJDGTLD-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

2-Ethyl-5-methoxy-N,N-dimethyltryptamine (EMDT), also known as 2-ethyl-5-MeO-DMT, is a tryptamine derivative which is used in scientific research. It acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor.12 Its affinities for many other targets have also been reported.2 EMDT inhibits both short- and long-term memory formation in animal studies, and this effect can be reversed by the selective 5-HT6 antagonist SB-399,885.3 Additionally, it is active in the tail suspension test, suggesting that it could be an effective antidepressant.4

See also

See also

References

References

  1. Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, et al. (March 2000). "2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors". Journal of Medicinal Chemistry. 43 (5): 1011–1018. doi:10.1021/jm990550b. PMID 10715164.
  2. Ray TS (February 2010). "Psychedelics and the human receptorome". PLOS ONE. 5 (2) e9019. Bibcode:2010PLoSO...5.9019R. doi:10.1371/journal.pone.0009019. PMC 2814854. PMID 20126400.
  3. Meneses A, Perez-Garcia G, Liy-Salmeron G, Flores-Galvez D, Castillo C, Castillo E (December 2008). "The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation". Behavioural Brain Research. 195 (1): 112–119. doi:10.1016/j.bbr.2007.11.023. PMID 18191236. S2CID 144901859.
  4. Svenningsson P, Tzavara ET, Qi H, Carruthers R, Witkin JM, Nomikos GG, Greengard P (April 2007). "Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation". The Journal of Neuroscience. 27 (15): 4201–4209. doi:10.1523/JNEUROSCI.3110-06.2007. PMC 6672541. PMID 17428998.