Article · Wikipedia archive · Last revised Jun 26, 2026

1F-LSD

1F-LSD, also known as 1-(furan-2-carbonyl)-LSD, 1-(2-furoyl)-LSD, or SYN-L-005, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is thought to act as a prodrug of LSD. The drug interacts with serotonin receptors, including the serotonin 5-HT2A receptor, and produces the head-twitch response in rodents, with about 3-fold lower potency than LSD. It hydrolyzes into LSD in rodents. 1F-LSD was patented in 2024 and was first described in the scientific literature in 2025. It has been encountered as a novel designer drug in Germany and Japan.

Last revised
Jun 26, 2026
Read time
≈ 1 min
Length
309 w
Citations
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Source
Wikipedia ↗
1F-LSD
Clinical data
Other names1-(Furan-2-carbonyl)-LSD; 1-(2-Furoyl)-LSD; SYN-L-005; N,N-Diethyl-1-(furan-2-carbonyl)-6-methyl-9,10-didehydroergoline-8β-carboxamide
Routes of
administration		Oral
Drug classSerotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • (6aR,9R)-N,N-diethyl-4-(furan-2-carbonyl)-7-methyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
PubChem CID
Chemical and physical data
FormulaC25H27N3O3
Molar mass417.509 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CN(C4=CC=CC(=C34)C2=C1)C(=O)C5=CC=CO5)C
  • InChI=1S/C25H27N3O3/c1-4-27(5-2)24(29)17-12-19-18-8-6-9-20-23(18)16(13-21(19)26(3)14-17)15-28(20)25(30)22-10-7-11-31-22/h6-12,15,17,21H,4-5,13-14H2,1-3H3/t17-,21-/m1/s1
  • Key:VHDXVHVDSPZVCI-DYESRHJHSA-N

1F-LSD, also known as 1-(furan-2-carbonyl)-LSD, 1-(2-furoyl)-LSD, or SYN-L-005, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).12 It is thought to act as a prodrug of LSD.12 The drug interacts with serotonin receptors, including the serotonin 5-HT2A receptor, and produces the head-twitch response in rodents, with about 3-fold lower potency than LSD.1 It hydrolyzes into LSD in rodents.1 1F-LSD was patented in 20242 and was first described in the scientific literature in 2025.1 It has been encountered as a novel designer drug in Germany and Japan.1

Use and effects

Interactions

Chemistry

Analogues

Analogues of 1F-LSD include 1P-LSD, 1cP-LSD, 1B-LSD, 1S-LSD, and 1T-LSD, among others.

Society and culture

Canada

1F-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.3

United States

1F-LSD is not an explicitly controlled substance in the United States.4 However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

See also

References

References

  1. Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL (August 2025). "Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD)". Drug Test Anal. 17 (8): 1283–1293. doi:10.1002/dta.3829. PMC 12319525. PMID 39624022.
  2. WO 2024/028495, Stratford A, Williamson JP, "Prodrugs of Substituted Ergolines", published 8 February 2024, assigned to Synex Holdings BV 
  3. "Controlled Drugs and Substances Act". Department of Justice Canada. 5 December 2025. Retrieved 20 January 2026.
  4. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) (PDF), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026
External links