TIMM44

TIMM44
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CW9
Identifiers
Aliases	TIMM44, TIM44, translocase of inner mitochondrial membrane 44
External IDs	OMIM: 605058; MGI: 1343262; HomoloGene: 4631; GeneCards: TIMM44; OMA:TIMM44 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,943,667 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	4,325,913 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; muscle layer of sigmoid colon; ; body of uterus; ; left ventricle; ; right ovary; ; left ovary; ; canal of the cervix; ; gastric mucosa;
	Top expressed in
	ciliary body; ; retinal pigment epithelium; ; right ventricle; ; neural layer of retina; ; sternocleidomastoid muscle; ; digastric muscle; ; temporal muscle; ; brown adipose tissue; ; internal carotid artery; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; chaperone binding; protein binding; ATP binding;
Cellular component	mitochondrial inner membrane; membrane; mitochondrion; mitochondrial matrix;
Biological process	protein transport; protein targeting to mitochondrion; protein import into mitochondrial matrix;
	Sources:Amigo / QuickGO
Orthologs
	10469
	21856
	ENSG00000104980
	ENSMUSG00000002949
	O43615
	O35857
	NM_006351
	NM_011592
	NP_006342
	NP_035722
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.⁵⁶⁷

Interactions

TIMM44 has been shown to interact with ARAF.⁵⁸

GRCh38: Ensembl release 89: ENSG00000104980 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000002949 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yuryev A, Ono M, Goff SA, Macaluso F, Wennogle LP (Jul 2000). "Isoform-Specific Localization of A-RAF in Mitochondria". Mol Cell Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
Bauer MF, Gempel K, Reichert AS, Rappold GA, Lichtner P, Gerbitz KD, Neupert W, Brunner M, Hofmann S (Jul 1999). "Genetic and structural characterization of the human mitochondrial inner membrane translocase". J Mol Biol. 289 (1): 69–82. doi:10.1006/jmbi.1999.2751. PMID 10339406.
"Entrez Gene: TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast)".
Yuryev, Anton; Wennogle Lawrence P (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2). United States: 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.

PDBe-KB provides an overview of all the structure information available in the PDB for Human Mitochondrial import inner membrane translocase subunit TIM44