GTF3C5

GTF3C5
Identifiers
Aliases	GTF3C5, TFIIIC63, TFIIICepsilon, TFiiiC2-63, general transcription factor IIIC subunit 5
External IDs	OMIM: 604890; MGI: 1917489; HomoloGene: 40806; GeneCards: GTF3C5; OMA:GTF3C5 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,058,503 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,473,763 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right uterine tube; ; left ovary; ; apex of heart; ; anterior pituitary; ; right ovary; ; body of uterus; ; canal of the cervix; ; tibial nerve; ; ectocervix;
	Top expressed in
	ventricular zone; ; tail of embryo; ; neural layer of retina; ; genital tubercle; ; epiblast; ; yolk sac; ; neural tube; ; internal carotid artery; ; external carotid artery; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA polymerase III type 1 promoter sequence-specific DNA binding; RNA polymerase III type 2 promoter sequence-specific DNA binding; RNA polymerase III general transcription initiation factor activity;
Cellular component	transcription factor TFIIIC complex; nucleus; nucleoplasm;
Biological process	skeletal muscle cell differentiation; tRNA transcription by RNA polymerase III; 5S class rRNA transcription by RNA polymerase III; transcription, DNA-templated; transcription by RNA polymerase III; RNA polymerase III preinitiation complex assembly; transcription initiation from RNA polymerase III promoter;
	Sources:Amigo / QuickGO
Orthologs
	9328
	70239
	ENSG00000148308
	ENSMUSG00000026816
	Q9Y5Q8
	Q8R2T8
	NM_001122823; NM_001286709; NM_012087
	NM_001290484; NM_148928
	NP_001116295; NP_001273638; NP_036219
	NP_001277413; NP_683730
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the GTF3C5 gene.⁵⁶

Interactions

GTF3C5 has been shown to interact with GTF3C2⁵ and GTF3C4.⁷

References

GRCh38: Ensembl release 89: ENSG00000148308 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026816 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
"Entrez Gene: GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa".
Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

Further reading

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148308 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026816 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10373544-5] Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

[entrez-6] "Entrez Gene: GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa".

[pmid10523658-7] Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

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