GTF3C2

GTF3C2
Identifiers
Aliases	GTF3C2, TFIIIC-BETA, TFIIIC110, general transcription factor IIIC subunit 2
External IDs	OMIM: 604883; MGI: 1919002; HomoloGene: 37490; GeneCards: GTF3C2; OMA:GTF3C2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,357,034 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,337,488 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; right lobe of thyroid gland; ; right uterine tube; ; skin of abdomen; ; left lobe of thyroid gland; ; minor salivary glands; ; body of pancreas; ; gastric mucosa; ; mucosa of transverse colon; ; granulocyte;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural layer of retina; ; yolk sac; ; internal carotid artery; ; external carotid artery; ; epiblast; ; secondary oocyte; ; ventricular zone; ; zygote;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA polymerase III general transcription initiation factor activity;
Cellular component	transcription factor TFIIIC complex; nucleus; nucleoplasm;
Biological process	tRNA transcription by RNA polymerase III; 5S class rRNA transcription by RNA polymerase III; transcription, DNA-templated; transcription by RNA polymerase III;
	Sources:Amigo / QuickGO
Orthologs
	2976
	71752
	ENSG00000115207
	ENSMUSG00000106864
	Q8WUA4
	Q8BL74
	NM_001035521; NM_001521; NM_001318909; NM_001388380
	NM_027901
	NP_001030598; NP_001305838; NP_001512
	NP_082177
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.⁵⁶

Interactions

GTF3C2 has been shown to interact with GTF3C4⁷ and GTF3C5.⁸

References

GRCh38: Ensembl release 89: ENSG00000115207 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000106864 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Sinn E, Wang Z, Kovelman R, Roeder RG (Jun 1995). "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors". Genes Dev. 9 (6): 675–85. doi:10.1101/gad.9.6.675. PMID 7729686.
"Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa".
Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

Further reading

Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. doi:10.1074/jbc.272.23.14755. PMID 9169441.
Oettel S, Härtel F, Kober I, Iben S, Seifart KH (1997). "Human transcription factors IIIC2, IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes". Nucleic Acids Res. 25 (12): 2440–7. doi:10.1093/nar/25.12.2440. PMC 146769. PMID 9171097.
Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Innes F, Ramsbottom B, White RJ (2006). "A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC". Nucleic Acids Res. 34 (11): 3399–407. doi:10.1093/nar/gkl432. PMC 1488882. PMID 16822860.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.

External links

GTF3C2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook TFIIIC-110

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115207 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000106864 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7729686-5] Sinn E, Wang Z, Kovelman R, Roeder RG (Jun 1995). "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors". Genes Dev. 9 (6): 675–85. doi:10.1101/gad.9.6.675. PMID 7729686.

[entrez-6] "Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa".

[pmid10523658-7] Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.

[pmid10373544-8] Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

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