YTHDC2

YTHDC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YU6
Identifiers
Aliases	YTHDC2, CAHL, YTH domain containing 2, hYTHDC2
External IDs	OMIM: 616530; MGI: 2448561; HomoloGene: 11265; GeneCards: YTHDC2; OMA:YTHDC2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,595,285 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	45,022,791 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; skin of thigh; ; skin of hip; ; hair follicle; ; tibia; ; Achilles tendon; ; Epithelium of choroid plexus; ; epithelium of nasopharynx; ; Brodmann area 23; ; germinal epithelium;
	Top expressed in
	secondary oocyte; ; spermatocyte; ; zygote; ; cumulus cell; ; pineal gland; ; semi-lunar valve; ; aortic valve; ; lumbar spinal ganglion; ; endothelial cell of lymphatic vessel; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein binding; RNA polymerase binding; ATP binding; hydrolase activity; helicase activity; nucleic acid binding; ATP-dependent activity, acting on RNA; RNA binding; N6-methyladenosine-containing RNA binding; 3'-5' RNA helicase activity;
Cellular component	endoplasmic reticulum; cytoplasm; nucleus; ribonucleoprotein granule;
Biological process	response to tumor necrosis factor; RNA processing; response to interleukin-1; positive regulation by host of viral genome replication; spermatogenesis; spermatid development; cell differentiation; oogenesis; oocyte development; meiosis; germline cell cycle switching, mitotic to meiotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	64848
	240255
	ENSG00000047188
	ENSMUSG00000034653
	Q9H6S0
	B2RR83
	NM_022828; NM_001345975; NM_001345976
	NM_001163013
	NP_001332904; NP_001332905; NP_073739
	NP_001156485
	Wikidata
View/Edit Human	View/Edit Mouse

YTH domain containing 2 is a protein that in humans is encoded by the YTHDC2 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000047188 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034653 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: YTH domain containing 2".

Further reading

Bhatnagar P, Purvis S, Barron-Casella E, DeBaun MR, Casella JF, Arking DE, Keefer JR (April 2011). "Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients". Journal of Human Genetics. 56 (4): 316–23. doi:10.1038/jhg.2011.12. PMC 5825003. PMID 21326311.
Morohashi K, Sahara H, Watashi K, Iwabata K, Sunoki T, Kuramochi K, Takakusagi K, Miyashita H, Sato N, Tanabe A, Shimotohno K, Kobayashi S, Sakaguchi K, Sugawara F (April 2011). Klein R (ed.). "Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B". PLOS ONE. 6 (4) e18285. Bibcode:2011PLoSO...618285M. doi:10.1371/journal.pone.0018285. PMC 3084704. PMID 21559518.
Gano JJ, Simon JA (February 2010). "A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein". Molecular & Cellular Proteomics. 9 (2): 255–70. doi:10.1074/mcp.M900261-MCP200. PMC 2830838. PMID 19875381.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000047188 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034653 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: YTH domain containing 2".

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