WD repeat-containing protein 77

WDR77
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GQB, 4X60, 4X61, 4X63, 5EMJ, 5EML, 5EMM, 5FA5, 5EMK, 5C9Z
Identifiers
Aliases	WDR77, MEP-50, MEP50, Nbla10071, p44, p44/Mep50, HKMT1069, WD repeat domain 77
External IDs	OMIM: 611734; MGI: 1917715; HomoloGene: 11466; GeneCards: WDR77; OMA:WDR77 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	111,449,256 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	105,877,353 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; apex of heart; ; gastrocnemius muscle; ; right adrenal cortex; ; muscle of thigh; ; mucosa of esophagus; ; body of stomach; ; left ventricle; ; left adrenal gland; ; rectum;
	Top expressed in
	primitive streak; ; epiblast; ; somite; ; tail of embryo; ; abdominal wall; ; endocardial cushion; ; Gonadal ridge; ; embryo; ; embryo; ; mandibular prominence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyl-CpG binding; protein binding; nuclear receptor coactivator activity; protein-arginine N-methyltransferase activity;
Cellular component	cytoplasm; cytosol; Golgi apparatus; methylosome; nucleoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; negative regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of cell population proliferation; negative regulation of cell population proliferation; peptidyl-arginine N-methylation; positive regulation of nucleic acid-templated transcription; spliceosomal snRNP assembly;
	Sources:Amigo / QuickGO
Orthologs
	79084
	70465
	ENSG00000116455
	ENSMUSG00000000561
	Q9BQA1
	Q99J09
	NM_024102; NM_001317062; NM_001317063; NM_001317064
	NM_027432
	NP_001303991; NP_001303992; NP_001303993; NP_077007
	NP_081708
	Wikidata
View/Edit Human	View/Edit Mouse

Methylosome protein 50 is a protein that in humans is encoded by the WDR77 gene.⁵⁶⁷

Interactions

WD repeat-containing protein 77 has been shown to interact with CTDP1⁸ and Protein arginine methyltransferase 5.⁵

References

GRCh38: Ensembl release 89: ENSG00000116455 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000561 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
"Entrez Gene: WDR77 WD repeat domain 77".
Licciardo P, Amente Stefano, Ruggiero Luca, Monti Maria, Pucci Piero, Lania Luigi, Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3). England: 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Licciardo P, Amente S, Ruggiero L, et al. (2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3): 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas". Oncogene. 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005. S2CID 3114318.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. doi:10.1016/j.febslet.2004.12.045. PMID 15670829.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Furuno K, Masatsugu T, Sonoda M, et al. (2006). "Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro". Biochem. Biophys. Res. Commun. 345 (3): 1051–8. doi:10.1016/j.bbrc.2006.05.014. PMID 16712789.
Zhou L, Wu H, Lee P, Wang Z (2007). "Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells". J. Mol. Endocrinol. 37 (2): 283–300. doi:10.1677/jme.1.02062. PMID 17032745.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Liang JJ, Wang Z, Chiriboga L, et al. (2007). "The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors". J. Urol. 177 (5): 1918–22. doi:10.1016/j.juro.2007.01.017. PMID 17437848.

Rengasamy, M, Zhang, F, Vashisht, A, Song, WM, et al. (2017). "The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer". Nucleic Acids Res. 45 (19): 11106–11120. doi:10.1093/nar/gkx727. PMC 5737218. PMID 28977470.

External links

Overview of all the structural information available in the PDB for UniProt: Q9BQA1 (Methylosome protein 50) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116455 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000561 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11756452-5] Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J Biol Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.

[pmid8619474-6] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[entrez-7] "Entrez Gene: WDR77 WD repeat domain 77".

[pmid12560496-8] Licciardo P, Amente Stefano, Ruggiero Luca, Monti Maria, Pucci Piero, Lania Luigi, Majello Barbara (Feb 2003). "The FCP1 phosphatase interacts with RNA polymerase II and with MEP50 a component of the methylosome complex involved in the assembly of snRNP". Nucleic Acids Res. 31 (3). England: 999–1005. doi:10.1093/nar/gkg197. PMC 149217. PMID 12560496.

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