Article · Wikipedia archive · Last revised Jun 3, 2026

Wayne Hendrickson

Wayne A. Hendrickson is an American biophysicist and university professor at Columbia University. Dr. Hendrickson is a university professor at Columbia University in the department of biochemistry and molecular biophysics. He is also Chief Life Scientist in the Photon Sciences Directorate at Brookhaven National Laboratory and scientific director of the New York Structural Biology Center.

Last revised
Jun 3, 2026
Read time
≈ 4 min
Length
980 w
Citations
30
Source
Wikipedia ↗
Wayne A. Hendrickson
Born (1941-04-25) April 25, 1941
Spring Valley, Wisconsin, USA
Alma materUniversity of Wisconsin-River Falls
Johns Hopkins University
Known forMulti-wavelength Anomalous Dispersion
AwardsChristian B. Anfinsen Award (1997)
Alexander Hollaender Award in Biophysics (1998)
Gairdner Foundation International Award (2003)
Harvey Prize (2004)
Scientific career
FieldsBiochemistry, Molecular Biophysics
InstitutionsColumbia University
Warner Love
Other academic advisors
Jerome Karle

Wayne A. Hendrickson (born April 25, 1941, New York City) is an American biophysicist and university professor at Columbia University. Dr. Hendrickson is a university professor at Columbia University in the department of biochemistry and molecular biophysics1. He is also Chief Life Scientist in the Photon Sciences Directorate at Brookhaven National Laboratory and scientific director of the New York Structural Biology Center1.

Early life and education

Hendrickson grew up on a farm in Spring Valley, Wisconsin, the son of Norwegian immigrants.2 He obtained a B.A. in biophysics from University of Wisconsin-River Falls23. He later received his Ph.D. in biophysics from Johns Hopkins University with Warner Love2, and postdoctoral research experience with Jerome Karle at the Naval Research Laboratory (NRL).

Scientific contributions

Hendrickson is best known for innovating the use of multi-wavelength anomalous dispersion as an analytical tool for protein crystallography45.

Hendrickson and his colleagues use biochemistry and x-ray crystallography to study molecular properties in atomic detail with current emphasis on membrane receptors and cellular signaling678, on viral proteins and HIV infection910, on molecular chaperones and protein folding111213, and on structural genomics of membrane proteins1415161718.

Recognition

Hendrickson's honors include the Aminoff Prize of the Royal Swedish Academy of Sciences19, Christian B. Anfinsen Award20 the Gairdner Foundation International Award21, the Harvey Prize22, and the thirteenth IUCr Ewald Prize in 2023.23 He is a fellow of the American Academy of Arts and Sciences2425 and a member of the National Academy of Sciences26. On June 2, 1995 he received an honorary doctorate from the Faculty of Science and Technology at Uppsala University, Sweden27

References

References

  1. "HENDRICKSON, WAYNE A., Ph.D." Department of Physiology and Cellular Biophysics. Columbia University Medical Center. Retrieved 19 May 2026.
  2. Zierler, David (13 April 2020). "Biography - Wayne Hendrickson". ACA History. American Crystallographic Association. Retrieved 19 May 2026.
  3. "Distinguished Alumni Recipients". University of Wisconsin River Falls. Retrieved 19 May 2026.
  4. Hendrickson W, Ogata C (1997). "Phase determination from multiwavelength anomalous diffraction measurements". Macromolecular Crystallography Part A. Methods in Enzymology. Vol. 276. pp. 494–523. doi:10.1016/S0076-6879(97)76074-9. ISBN 978-0-12-182177-7. PMID 27799111.
  5. Hendrickson WA (1985). "Analysis of Protein Structure from Diffraction Measurement at Multiple Wavelengths". Transactions of the ACA. 21.
  6. Leahy, Daniel J.; Axel, Richard; Hendrickson, Wayne A. (March 1992). "Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution". Cell. 68 (6): 1145–1162. doi:10.1016/0092-8674(92)90085-Q.
  7. Ryu, Seong-Eon; Kwong, Peter D.; Truneh, Alemseged; Porter, Terence G.; Arthos, James; Rosenberg, Martin; Dai, Xiaoping; Xuong, Nguyen-huu; Axel, Richard; Sweet, Raymond W.; Hendrickson, Wayne A. (November 1990). "Crystal structure of an HIV-binding recombinant fragment of human CD4". Nature. 348 (6300): 419–426. doi:10.1038/348419a0.
  8. Wu, Hao; Kwong, Peter D.; Hendrickson, Wayne A. (May 1997). "Dimeric association and segmental variability in the structure of human CD4". Nature. 387 (6632): 527–530. doi:10.1038/387527a0.
  9. Wyatt, Richard; Kwong, Peter D.; Desjardins, Elizabeth; Sweet, Raymond W.; Robinson, James; Hendrickson, Wayne A.; Sodroski, Joseph G. (June 1998). "The antigenic structure of the HIV gp120 envelope glycoprotein". Nature. 393 (6686): 705–711. doi:10.1038/31514.
  10. Kwong, Peter D.; Wyatt, Richard; Robinson, James; Sweet, Raymond W.; Sodroski, Joseph; Hendrickson, Wayne A. (June 1998). "Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody". Nature. 393 (6686): 648–659. doi:10.1038/31405.
  11. Qi, Ruifeng; Sarbeng, Evans Boateng; Liu, Qun; Le, Katherine Quynh; Xu, Xinping; Xu, Hongya; Yang, Jiao; Wong, Jennifer Li; Vorvis, Christina; Hendrickson, Wayne A; Zhou, Lei; Liu, Qinglian (July 2013). "Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP". Nature Structural & Molecular Biology. 20 (7): 900–907. doi:10.1038/nsmb.2583.
  12. Liu, Qinglian; Hendrickson, Wayne A. (October 2007). "Insights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1". Cell. 131 (1): 106–120. doi:10.1016/j.cell.2007.08.039.
  13. Wang, Wei; Liu, Qinglian; Liu, Qun; Hendrickson, Wayne A. (October 2021). "Conformational equilibria in allosteric control of Hsp70 chaperones". Molecular Cell. 81 (19): 3919–3933.e7.
  14. Chang, Yanqi; Bruni, Renato; Kloss, Brian; Assur, Zahra; Kloppmann, Edda; Rost, Burkhard; Hendrickson, Wayne A.; Liu, Qun (6 June 2014). "Structural basis for a pH-sensitive calcium leak across membranes". Science. 344 (6188): 1131–1135. doi:10.1126/science.1252043.
  15. Yang, Tingting; Liu, Qun; Kloss, Brian; Bruni, Renato; Kalathur, Ravi C.; Guo, Youzhong; Kloppmann, Edda; Rost, Burkhard; Colecraft, Henry M.; Hendrickson, Wayne A. (17 October 2014). "Structure and selectivity in bestrophin ion channels". Science. 346 (6207): 355–359. doi:10.1126/science.1259723.
  16. Hendrickson, Wayne A (June 2016). "Atomic-level analysis of membrane-protein structure". Nature Structural & Molecular Biology. 23 (6): 464–467. doi:10.1038/nsmb.3215.
  17. Love, James; Mancia, Filippo; Shapiro, Lawrence; Punta, Marco; Rost, Burkhard; Girvin, Mark; Wang, Da-Neng; Zhou, Ming; Hunt, John F.; Szyperski, Thomas; Gouaux, Eric; MacKinnon, Roderick; McDermott, Ann; Honig, Barry; Inouye, Masayori; Montelione, Gaetano; Hendrickson, Wayne A. (September 2010). "The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins". Journal of Structural and Functional Genomics. 11 (3): 191–199. doi:10.1007/s10969-010-9094-7.
  18. Qiu, Weihua; Fu, Ziao; Xu, Guoyan G.; Grassucci, Robert A.; Zhang, Yan; Frank, Joachim; Hendrickson, Wayne A.; Guo, Youzhong (18 December 2018). "Structure and activity of lipid bilayer within a membrane-protein transporter". Proceedings of the National Academy of Sciences. 115 (51): 12985–12990. doi:10.1073/pnas.1812526115.
  19. Olovsson, Ivar (5 February 2019). "The Gregori Aminoff prize". IUCr Newsletter. 5 (2). Retrieved 19 May 2026.
  20. "Recent honours". IUCr Newsletter. 5 (1). 2 November 2018. Retrieved 19 May 2026.
  21. "Canada Gairdner International Award". Gairdner. Retrieved 19 May 2026.
  22. "Prize Winners". Harvey Prize. Retrieved 19 May 2026.
  23. "Thirteenth Ewald Prize"
  24. "Wayne A. Hendrickson". American Academy of Arts & Sciences. Retrieved 19 May 2026.
  25. "Book of Members, 1780–2010: Chapter h" (PDF). American Academy of Arts and Sciences. Retrieved June 19, 2011.
  26. "Wayne A. Hendrickson". National Academy of Sciences. Retrieved 19 May 2026.
  27. "Honorary doctorates - Uppsala University, Sweden".
External links