Article · Wikipedia archive · Last revised May 30, 2026

VIS1

VIS1, also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs. Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas.

Last revised
May 30, 2026
Read time
≈ 1 min
Length
251 w
Citations
5
Source
Wikipedia ↗
VIS1
Identifiers
AliasesVIS1, HIS-1, HIS1, viral integration site 1
External IDsOMIM: 164755; GeneCards: VIS1; OMA:VIS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7435

n/a

Ensembl

ENSG00000276706

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed search1n/a
Wikidata
View/Edit Human

VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM23 It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs.4 Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas.5

See also

See also

References

References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. Askew DS, Bartholomew C, Buchberg AM, et al. (November 1991). "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". Oncogene. 6 (11): 2041–2047. PMID 1682866.
  3. Askew DS, Li J, Ihle JN (March 1994). "Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame". Mol. Cell. Biol. 14 (3): 1743–1751. doi:10.1128/MCB.14.3.1743. PMC 358532. PMID 8114708.
  4. Li J, Rhodes JC, Askew DS (January 1997). "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". Gene. 184 (2): 169–176. doi:10.1016/S0378-1119(96)00591-4. PMID 9031624.
  5. Li J, Witte DP, Van Dyke T, Askew DS (April 1997). "Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues". Am. J. Pathol. 150 (4): 1297–1305. PMC 1858164. PMID 9094986.