Article · Wikipedia archive · Last revised Jul 1, 2026

UniCarb-DB

UniCarb-DB is a structural and mass spectrometric database used in glycomics. UniCarb-DB provides over 1000 LC-MS/MS spectra for N- and O-linked glycans released from glycoproteins that were manually annotated. Each entry contains reference to published work, information about structure, GlyToucan Accession Number, MS/MS fragmentation with complete peak lists, biological contexts and experimental metadata. The database was created by a collaboration between University of Gothenburg and Macquarie University and since November 2016 is hosted by Swiss Institute for Bioinformatics. The database is the first to implement the Minimum Information standard MIRAGE for submission of glycomic MS/MS data into the database.

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UniCarb-DB1 is a structural and mass spectrometric database used in glycomics. UniCarb-DB provides over 1000 LC-MS/MS spectra for N- and O-linked glycans released from glycoproteins that were manually annotated. Each entry contains reference to published work, information about structure, GlyToucan Accession Number, MS/MS fragmentation with complete peak lists, biological contexts and experimental metadata.2 The database was created by a collaboration between University of Gothenburg and Macquarie University34 and since November 2016 is hosted by Swiss Institute for Bioinformatics. The database is the first to implement the Minimum Information standard MIRAGE (Minimum Information Required About a Glycomics Experiment) for submission of glycomic MS/MS data into the database.5

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References

  1. "UniCarb-DB". unicarb-db.expasy.org. Retrieved 2016-11-14.
  2. Lisacek, Frederique; Mariethoz, Julien; Alocci, Davide; Rudd, PaulineM.; Abrahams, JodieL.; Campbell, MatthewP.; Packer, NicolleH.; Ståhle, Jonas; Widmalm, Göran (2017-01-01). "Databases and Associated Tools for Glycomics and Glycoproteomics". In Lauc, Gordan; Wuhrer, Manfred (eds.). High-Throughput Glycomics and Glycoproteomics. Methods in Molecular Biology. Vol. 1503. Springer New York. pp. 235–264. doi:10.1007/978-1-4939-6493-2_18. ISBN 9781493964918. PMID 27743371.
  3. Campbell, Matthew P.; Nguyen-Khuong, Terry; Hayes, Catherine A.; Flowers, Sarah A.; Alagesan, Kathirvel; Kolarich, Daniel; Packer, Nicolle H.; Karlsson, Niclas G. (2014-01-01). "Validation of the curation pipeline of UniCarb-DB: building a global glycan reference MS/MS repository". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1844 (1 Pt A): 108–116. doi:10.1016/j.bbapap.2013.04.018. ISSN 0006-3002. PMID 23624262.
  4. Hayes, Catherine A.; Karlsson, Niclas G.; Struwe, Weston B.; Lisacek, Frederique; Rudd, Pauline M.; Packer, Nicolle H.; Campbell, Matthew P. (2011-05-01). "UniCarb-DB: a database resource for glycomic discovery". Bioinformatics. 27 (9): 1343–1344. doi:10.1093/bioinformatics/btr137. ISSN 1367-4811. PMID 21398669.
  5. Rojas-Macias, Miguel A.; Mariethoz, Julien; Andersson, Peter; Jin, Chunsheng; Venkatakrishnan, Vignesh; Aoki, Nobuyuki P.; Shinmachi, Daisuke; Ashwood, Christopher; Madunic, Katarina (2018-08-27). "e-workflow for recording of glycomic mass spectrometric data in compliance with reporting guidelines". bioRxiv 10.1101/401141.
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