UNC45A

UNC45A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DBA
Identifiers
Aliases	UNC45A, GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A, OOHE
External IDs	OMIM: 611219; MGI: 2142246; HomoloGene: 32423; GeneCards: UNC45A; OMA:UNC45A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,954,093 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,997,741 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; muscle layer of sigmoid colon; ; Descending thoracic aorta; ; ascending aorta; ; right hemisphere of cerebellum; ; body of uterus; ; skin of leg; ; gastric mucosa; ; stromal cell of endometrium;
	Top expressed in
	external carotid artery; ; mucous cell of stomach; ; internal carotid artery; ; olfactory epithelium; ; lip; ; Rostral migratory stream; ; molar; ; neural layer of retina; ; tunica media of zone of aorta; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	Hsp90 protein binding; protein binding; cadherin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nucleus; Golgi apparatus; cytosol; nuclear speck;
Biological process	multicellular organism development; cell differentiation; muscle organ development; chaperone-mediated protein folding;
	Sources:Amigo / QuickGO
Orthologs
	55898
	101869
	ENSG00000140553
	ENSMUSG00000030533
	Q9H3U1
	Q99KD5
NM_001039675; NM_017979; NM_018671; NM_001323619; NM_001323620;
	NM_001323621
	NM_133952
	NP_001034764; NP_001310548; NP_001310549; NP_001310550; NP_061141
	NP_598713
	Wikidata
View/Edit Human	View/Edit Mouse

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000140553 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030533 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci. 115 (Pt 21): 4013–23. doi:10.1242/jcs.00108. PMID 12356907. S2CID 44196958.
"Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

Further reading

Bazzaro M, Santillan A, Lin Z, et al. (2008). "Myosin II Co-Chaperone General Cell UNC-45 Overexpression Is Associated with Ovarian Cancer, Rapid Proliferation, and Motility". Am. J. Pathol. 171 (5): 1640–9. doi:10.2353/ajpath.2007.070325. PMC 2043524. PMID 17872978.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chadli A, Graham JD, Abel MG, et al. (2006). "GCUNC-45 Is a Novel Regulator for the Progesterone Receptor/hsp90 Chaperoning Pathway". Mol. Cell. Biol. 26 (5): 1722–30. doi:10.1128/MCB.26.5.1722-1730.2006. PMC 1430258. PMID 16478993.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140553 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030533 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12356907-5] Price MG, Landsverk ML, Barral JM, Epstein HF (Oct 2002). "Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions". J Cell Sci. 115 (Pt 21): 4013–23. doi:10.1242/jcs.00108. PMID 12356907. S2CID 44196958.

[entrez-6] "Entrez Gene: UNC45A unc-45 homolog A (C. elegans)".

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