ULBP1

ULBP1
Identifiers
Aliases	ULBP1, RAET1I, N2DL-1, NKG2DL1, UL16 binding protein 1
External IDs	OMIM: 605697; MGI: 1925027; HomoloGene: 108274; GeneCards: ULBP1; OMA:ULBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,973,715 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,423,638 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; pancreatic ductal cell; ; right lung; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; upper lobe of left lung; ; islet of Langerhans; ; ventricular zone; ; ganglionic eminence; ; right testis;
	Top expressed in
	thymus; ; yolk sac; ; granulocyte; ; spermatocyte; ; secondary oocyte; ; placenta; ; embryo; ; epiblast; ; primary oocyte; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding; protein binding;
Cellular component	anchored component of membrane; anchored component of plasma membrane; endoplasmic reticulum; membrane; cytosol; plasma membrane; actin cytoskeleton; extracellular space; external side of plasma membrane;
Biological process	natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response; immune system process; viral process; T cell mediated cytotoxicity; immune response; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	80329
	77777
	ENSG00000111981
	ENSMUSG00000079685
	Q9BZM6
	n/a
	NM_025218; NM_001317089
	NM_029975
	NP_001304018; NP_079494
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6.⁵⁶ ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus.⁵⁶ The domain structure of ULBP1 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP1 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.⁵⁶ It functions as a stress-induced ligand for NKG2D receptor.⁵ ULBP1 is, for example, upregulated during HCMV infection.⁷ Binding of HCMV-encoded UL16 glycoprotein to ULBP1 interferes with cell surface localization of ULBP1; this represents another mechanism by which HCMV-infected cells might escape the immune system.⁷

References

GRCh38: Ensembl release 89: ENSG00000111981 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000079685 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.
Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.

Further reading

Cerwenka A, Lanier LL (May 2003). "NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer". Tissue Antigens. 61 (5): 335–43. doi:10.1034/j.1399-0039.2003.00070.x. PMID 12753652.
Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T (2001). "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family". Immunogenetics. 53 (4): 279–87. doi:10.1007/s002510100325. PMID 11491531. S2CID 33695596.
Sutherland CL, Chalupny NJ, Schooley K, VandenBos T, Kubin M, Cosman D (Jan 2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells". Journal of Immunology. 168 (2): 671–9. doi:10.4049/jimmunol.168.2.671. PMID 11777960.
Dunn C, Chalupny NJ, Sutherland CL, Dosch S, Sivakumar PV, Johnson DC, Cosman D (Jun 2003). "Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity". The Journal of Experimental Medicine. 197 (11): 1427–39. doi:10.1084/jem.20022059. PMC 2193902. PMID 12782710.
Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.
Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM (Apr 2004). "Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D". The Journal of Experimental Medicine. 199 (7): 1005–10. doi:10.1084/jem.20032194. PMC 2211882. PMID 15051759.
Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J (Jul 2004). "Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D". Journal of Immunology. 173 (2): 1078–84. doi:10.4049/jimmunol.173.2.1078. PMID 15240696.
López-Soto A, Quiñones-Lombraña A, López-Arbesú R, López-Larrea C, González S (Oct 2006). "Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor". The Journal of Biological Chemistry. 281 (41): 30419–30. doi:10.1074/jbc.M604868200. hdl:10651/42009. PMID 16901903.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111981 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079685 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11239445-5] Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Feb 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity. 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.

[pmid11827464-6] Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Jan 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics. 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464.

[:0-7] Rölle A, Mousavi-Jazi M, Eriksson M, Odeberg J, Söderberg-Nauclér C, Cosman D, Kärre K, Cerboni C (Jul 2003). "Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein". Journal of Immunology. 171 (2): 902–8. doi:10.4049/jimmunol.171.2.902. PMID 12847260.

1

2

3

4

5

6

7