TTC1

TTC1
Identifiers
Aliases	TTC1, TPR1, tetratricopeptide repeat domain 1
External IDs	OMIM: 601963; MGI: 1914077; HomoloGene: 2485; GeneCards: TTC1; OMA:TTC1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	160,065,543 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	43,638,835 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; Achilles tendon; ; cingulate gyrus; ; left ventricle; ; anterior cingulate cortex; ; right frontal lobe; ; C1 segment; ; Brodmann area 9; ; prefrontal cortex; ; islet of Langerhans;
	Top expressed in
	blastocyst; ; genital tubercle; ; tail of embryo; ; morula; ; spermatocyte; ; spermatid; ; secondary oocyte; ; muscle of thigh; ; zygote; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; protein binding;
Cellular component	peroxisomal membrane; cytosol;
Biological process	protein folding;
	Sources:Amigo / QuickGO
Orthologs
	7265
	66827
	ENSG00000113312
	ENSMUSG00000041278
	Q99614
	Q91Z38
	NM_003314; NM_001282500
	NM_133795
	NP_001269429; NP_003305
	NP_598556
	Wikidata
View/Edit Human	View/Edit Mouse

Tetratricopeptide repeat protein 1 is a protein that in humans is encoded by the TTC1 gene.⁵⁶

Interactions

TTC1 has been shown to interact with HSPA4.⁷

References

GRCh38: Ensembl release 89: ENSG00000113312 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041278 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.
"Entrez Gene: TTC1 tetratricopeptide repeat domain 1".
Oh WK, Song Jaewhan (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1). Korea (South): 84–91. doi:10.1016/S1016-8478(23)13770-8. ISSN 1016-8478. PMID 14503850.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Marty C, Browning DD, Ye RD (2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Mol. Cell. Biol. 23 (11): 3847–58. doi:10.1128/MCB.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
Oh WK, Song J (2004). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1): 84–91. doi:10.1016/S1016-8478(23)13770-8. PMID 14503850.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113312 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041278 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8836031-5] Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.

[entrez-6] "Entrez Gene: TTC1 tetratricopeptide repeat domain 1".

[pmid14503850-7] Oh WK, Song Jaewhan (Aug 2003). "Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation". Mol. Cells. 16 (1). Korea (South): 84–91. doi:10.1016/S1016-8478(23)13770-8. ISSN 1016-8478. PMID 14503850.

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