TRPP3

PKD2L2
Identifiers
Aliases	PKD2L2, TRPP5, polycystin 2 like 2, transient receptor potential cation channel
External IDs	OMIM: 604669; MGI: 1858231; HomoloGene: 22812; GeneCards: PKD2L2; OMA:PKD2L2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,942,747 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,577,169 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; buccal mucosa cell; ; testicle; ; left testis; ; right testis; ; sperm; ; internal globus pallidus; ; gonad; ; muscle of thigh; ; Achilles tendon;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; spermatocyte; ; spermatid; ; granulocyte; ; seminiferous tubule; ; egg cell; ; supraoptic nucleus; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; calcium channel activity;
Cellular component	integral component of membrane; membrane;
Biological process	ion transport; detection of mechanical stimulus; calcium ion transmembrane transport; biological process;
	Sources:Amigo / QuickGO
Orthologs
	27039
	53871
	ENSG00000078795
	ENSMUSG00000014503
	Q9NZM6
	Q9JLG4
	NM_001258448; NM_001258449; NM_001300921; NM_014386
	NM_001163004; NM_016927
	NP_001245377; NP_001245378; NP_001287850; NP_055201
	NP_001156476; NP_058623
	Wikidata
View/Edit Human	View/Edit Mouse

Polycystic kidney disease 2-like 2 protein (PKD2L2) also known as transient receptor potential polycystic 5 (TRPP5) is a protein that in humans is encoded by the PKD2L2 gene.⁵

TRPP5 is a member of the transient receptor potential channel family of proteins.

References

GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi:10.1038/sj.ejhg.5200383. PMID 10602361.

Further reading

Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS Lett. 516 (1–3): 270–8. Bibcode:2002FEBSL.516..270L. doi:10.1016/S0014-5793(02)02513-9. PMID 11959145. S2CID 1812119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Stayner C, Zhou J (2001). "Polycystin channels and kidney disease". Trends Pharmacol. Sci. 22 (11): 543–6. doi:10.1016/S0165-6147(00)01832-0. PMID 11698076.
Guo L, Schreiber TH, Weremowicz S, et al. (2000). "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization". Genomics. 64 (3): 241–51. doi:10.1006/geno.2000.6131. PMID 10756092.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10602361-5] Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi:10.1038/sj.ejhg.5200383. PMID 10602361.

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See also

References

Further reading