TRIM45

TRIM45
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DS4
Identifiers
Aliases	TRIM45, RNF99, tripartite motif containing 45
External IDs	OMIM: 609318; MGI: 1918187; HomoloGene: 11865; GeneCards: TRIM45; OMA:TRIM45 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,122,587 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,844,236 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right uterine tube; ; apex of heart; ; testicle; ; muscle of thigh; ; gastrocnemius muscle; ; right auricle of heart; ; gonad; ; tibialis anterior muscle; ; deltoid muscle;
	Top expressed in
	otolith organ; ; utricle; ; vestibular sensory epithelium; ; olfactory system; ; olfactory epithelium; ; seminiferous tubule; ; internal carotid artery; ; external carotid artery; ; spermatid; ; Jacobson's organ;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; metal ion binding;
Cellular component	intracellular anatomical structure; nucleus; nucleoplasm; intercellular bridge; cytoplasm; cytosol;
Biological process	bone development;
	Sources:Amigo / QuickGO
Orthologs
	80263
	229644
	ENSG00000134253
	ENSMUSG00000033233
	Q9H8W5
	Q6PFY8
	NM_001145635; NM_025188
	NM_001165952; NM_001165953; NM_194343
	NP_001139107; NP_079464
	NP_001159424; NP_001159425; NP_919324
	Wikidata
View/Edit Human	View/Edit Mouse

tripartite motif containing 45, also known as TRIM45, is a human gene.⁵

This gene encodes a member of the tripartite motif family. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.⁵

References

GRCh38: Ensembl release 89: ENSG00000134253 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033233 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: tripartite motif containing 45". Retrieved 2011-08-30.

Further reading

Sardiello M, Cairo S, Fontanella B, Ballabio A, Meroni G (2008). "Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties". BMC Evolutionary Biology. 8 (1) 225. Bibcode:2008BMCEE...8..225S. doi:10.1186/1471-2148-8-225. PMC 2533329. PMID 18673550.
Wang Y, Li Y, Qi X, Yuan W, Ai J, Zhu C, Cao L, Yang H, Liu F, Wu X, Liu M (Oct 2004). "TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1". Biochemical and Biophysical Research Communications. 323 (1): 9–16. Bibcode:2004BBRC..323....9W. doi:10.1016/j.bbrc.2004.08.048. PMID 15351693.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134253 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033233 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: tripartite motif containing 45". Retrieved 2011-08-30.

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