TRIM31

TRIM31
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YSJ, 2YSL
Identifiers
Aliases	TRIM31, C6orf13, HCG1, HCGI, RNF, tripartite motif containing 31
External IDs	OMIM: 609316; MGI: 2385051; HomoloGene: 17137; GeneCards: TRIM31; OMA:TRIM31 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,113,090 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	37,221,106 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; duodenum; ; appendix; ; gallbladder; ; urinary bladder; ; testicle; ; epithelium of colon; ; right testis; ; left testis;
	Top expressed in
	intestinal villus; ; jejunum; ; duodenum; ; left colon; ; ileum; ; epithelium of small intestine; ; Paneth cell; ; crypt of lieberkuhn of small intestine; ; migratory enteric neural crest cell; ; zygote;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; protein binding; metal ion binding; transferase activity;
Cellular component	cytoplasm; cytosol; intracellular anatomical structure; mitochondrion;
Biological process	positive regulation of DNA-binding transcription factor activity; protein ubiquitination; interferon-gamma-mediated signaling pathway; negative regulation of viral transcription; innate immune response; negative regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	11074
	224762
ENSG00000223531; ENSG00000137397; ENSG00000233573; ENSG00000224168; ENSG00000225130;
	ENSG00000226402; ENSG00000224542; ENSG00000204616
	ENSMUSG00000058063
	Q9BZY9; Q2L6J1
	Q8R0K2
	NM_007028
	NM_146077
	NP_008959; NP_008959.3
	NP_666189
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 31 is a protein that in humans is encoded by the TRIM31 gene.⁵⁶

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.⁶

Interactions

TRIM31 has been shown to interact with TRIM23.⁵

References

ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 GRCh38: Ensembl release 89: ENSG00000223531, ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000058063 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
"Entrez Gene: TRIM31 tripartite motif-containing 31".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
el Kahloun A, Chauvel B, Mauvieux V, et al. (1993). "Localization of seven new genes around the HLA-A locus". Hum. Mol. Genet. 2 (1): 55–60. doi:10.1093/hmg/2.1.55. PMID 8490624.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC 1526686. PMID 16702430.

[refGRCh38Ensembl-1] ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 GRCh38: Ensembl release 89: ENSG00000223531, ENSG00000137397, ENSG00000233573, ENSG00000224168, ENSG00000225130, ENSG00000226402, ENSG00000224542, ENSG00000204616 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000058063 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-6] "Entrez Gene: TRIM31 tripartite motif-containing 31".

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