TRIM11

TRIM11
Identifiers
Aliases	TRIM11, BIA1, RNF92, tripartite motif containing 11
External IDs	OMIM: 607868; MGI: 2137355; HomoloGene: 14225; GeneCards: TRIM11; OMA:TRIM11 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	228,406,835 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	58,882,284 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; granulocyte; ; oocyte; ; mucosa of transverse colon; ; spleen; ; mucosa of ileum; ; blood; ; cerebellar vermis; ; monocyte;
	Top expressed in
	granulocyte; ; secondary oocyte; ; spermatocyte; ; zygote; ; tibiofemoral joint; ; corneal stroma; ; thymus; ; atrium; ; primary oocyte; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; zinc ion binding; transcription factor binding; protein binding; protein domain specific binding; ubiquitin protein ligase activity; metal ion binding; transferase activity;
Cellular component	cytoplasm; intracellular anatomical structure; nucleus; cytosol;
Biological process	negative regulation of neurogenesis; innate immune response; negative regulation of transcription, DNA-templated; defense response to virus; protein ubiquitination; negative regulation of viral transcription; negative regulation of viral entry into host cell; positive regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	81559
	94091
	ENSG00000154370
	ENSMUSG00000020455
	Q96F44
	Q99PQ2
	NM_145214
	NM_001290988; NM_053168
	NP_660215
	NP_001277917; NP_444398
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.⁵⁶

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified.⁶

References

GRCh38: Ensembl release 89: ENSG00000154370 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020455 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
"Entrez Gene: TRIM11 tripartite motif-containing 11".

Further reading

Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669. S2CID 33550003.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Niikura T, Hashimoto Y, Tajima H, et al. (2003). "A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults". Eur. J. Neurosci. 17 (6): 1150–8. doi:10.1046/j.1460-9568.2003.02553.x. PMID 12670303. S2CID 1345339.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154370 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020455 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-6] "Entrez Gene: TRIM11 tripartite motif-containing 11".

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