TOE1

TOE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FC6
Identifiers
Aliases	TOE1, hCaf1z, target of EGR1, member 1 (nuclear), PCH7, target of EGR1, exonuclease, TOE-1
External IDs	OMIM: 613931; MGI: 1915526; HomoloGene: 11823; GeneCards: TOE1; OMA:TOE1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	45,343,973 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	116,664,837 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; gonad; ; parotid gland; ; mucosa of transverse colon; ; right lobe of thyroid gland; ; left testis; ; granulocyte; ; right testis; ; smooth muscle tissue; ; rectum;
	Top expressed in
	primitive streak; ; renal corpuscle; ; morula; ; blastocyst; ; spermatocyte; ; epiblast; ; superior cervical ganglion; ; medullary collecting duct; ; seminal vesicula; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	3'-5'-exoribonuclease activity; protein binding; metal ion binding; nucleic acid binding; poly(A)-specific ribonuclease activity; snRNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; Cajal body; nuclear speck; nucleolus; nucleoplasm; nucleus; nuclear body;
Biological process	RNA phosphodiester bond hydrolysis, exonucleolytic; snRNA 3'-end processing; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	114034
	68276
	ENSG00000132773
	ENSMUSG00000028688
	Q96GM8
	Q9D2E2
	NM_025077
	NM_026654
	NP_079353
	NP_080930
	Wikidata
View/Edit Human	View/Edit Mouse

Target of EGR1 protein 1 is a protein that in humans is encoded by the TOE1 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000132773 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028688 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.
"Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. hdl:10669/15162. PMID 7829101.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132773 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028688 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12562764-5] De Belle I, Wu JX, Sperandio S, Mercola D, Adamson ED (Apr 2003). "In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1". J Biol Chem. 278 (16): 14306–12. doi:10.1074/jbc.M210502200. PMID 12562764.

[entrez-6] "Entrez Gene: TOE1 target of EGR1, member 1 (nuclear)".

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