TNIP2

TNIP2
Identifiers
Aliases	TNIP2, ABIN2, FLIP1, KLIP, TNFAIP3 interacting protein 2
External IDs	OMIM: 610669; MGI: 2386643; HomoloGene: 11515; GeneCards: TNIP2; OMA:TNIP2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	2,756,342 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	34,671,335 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; pancreatic ductal cell; ; granulocyte; ; mucosa of transverse colon; ; apex of heart; ; gastric mucosa; ; muscle layer of sigmoid colon; ; body of stomach; ; upper lobe of left lung; ; monocyte;
	Top expressed in
	neural layer of retina; ; interventricular septum; ; granulocyte; ; lip; ; right kidney; ; primary visual cortex; ; muscle of thigh; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein kinase binding; metal ion binding; polyubiquitin modification-dependent protein binding; K63-linked polyubiquitin modification-dependent protein binding;
Cellular component	nucleus; cytosol; cytoplasm; nucleoplasm;
Biological process	negative regulation of endothelial cell apoptotic process; regulation of transcription, DNA-templated; CD40 signaling pathway; protein stabilization; positive regulation of macrophage activation; transcription, DNA-templated; stress-activated MAPK cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of B cell activation; inflammatory response; I-kappaB kinase/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; apoptotic process; toll-like receptor 9 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; protein deubiquitination; cellular response to lipopolysaccharide; interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	79155
	231130
	ENSG00000168884
	ENSMUSG00000059866
	Q8NFZ5
	Q99JG7
	NM_024309; NM_001161527; NM_001292016
	NM_139064
	NP_001154999; NP_001278945; NP_077285
	NP_620703
	Wikidata
View/Edit Human	View/Edit Mouse

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.⁵⁶⁷ TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.⁸

References

GRCh38: Ensembl release 89: ENSG00000168884 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059866 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. hdl:2381/17005. PMID 12933576.
"Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".
"TNIP2 (human)". www.phosphosite.org. Retrieved 2020-10-31.

Further reading

Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. hdl:1854/LU-113881. PMC 2133159. PMID 10385526.
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905. S2CID 32414520.
Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID 12595760. S2CID 202644741.
Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi:10.1161/01.RES.0000063422.38690.DC. hdl:2381/866. PMID 12609966.
Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905. S2CID 31400521.
Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC 1224013. PMID 14653779.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.
Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954.
Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025.
Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. Bibcode:2007JRadR..48...13L. doi:10.1269/jrr.0615. PMID 17038805.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168884 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059866 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11390377-5] Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.

[pmid12933576-6] Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. hdl:2381/17005. PMID 12933576.

[entrez-7] "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".

[8] "TNIP2 (human)". www.phosphosite.org. Retrieved 2020-10-31.

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