TMEM51

TMEM51
Identifiers
Aliases	TMEM51, C1orf72, transmembrane protein 51
External IDs	MGI: 2384874; HomoloGene: 9966; GeneCards: TMEM51; OMA:TMEM51 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	15,220,478 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,811,615 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; oocyte; ; body of stomach; ; cartilage tissue; ; mucosa of transverse colon; ; stromal cell of endometrium; ; gallbladder; ; buccal mucosa cell; ; islet of Langerhans; ; right adrenal cortex;
	Top expressed in
	stomach; ; right kidney; ; proximal tubule; ; ileum; ; duodenum; ; yolk sac; ; jejunum; ; human kidney; ; urinary bladder; ; colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molecular function;
Cellular component	membrane; integral component of membrane; cellular component;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	55092
	214359
	ENSG00000171729
	ENSMUSG00000040616
	Q9NW97; Q9BSA0
	Q99LG1
	NM_001136216; NM_001136217; NM_001136218; NM_018022; NM_001319665
	NM_145402
NP_001129688; NP_001129689; NP_001129690; NP_001306594; NP_060492;
	NP_001306594.1
	NP_663377
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane protein 51 is a protein in humans that is encoded by the TMEM51 gene.⁵ It is located on the first chromosome (1p36.21) and has 6 isoforms in humans.⁶ It has orthologs in mammals, birds, reptiles, amphibians, and fish.⁶

It is predicted to be a transmembrane protein due to the transmembrane regions within its coding sequence.⁷

TMEM51-AS1 (a long non-coding RNA from the TMEM51 locus) acts as a tumor suppressor when overexpressed, inhibiting cancer cell progression.⁸ Mutations or polymorphisms of the TMEM51 are associated susceptibility to Reynaud's syndrome.⁹

References

GRCh38: Ensembl release 89: ENSG00000171729 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040616 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Transmembrane protein 51". Retrieved 2012-10-29.
"AceView: Gene:TMEM51, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2025-09-29.
"Homo sapiens transmembrane protein 51 (TMEM51), transcript variant 1, mRNA". NCBI. 2025-04-27.
Wu D, Xia Q, Su X, Mao Y, Mao J, Ding Q, et al. (May 2025). "Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression". Discover Oncology. 16 (1) 878. doi:10.1007/s12672-025-02676-z. PMC 12102048. PMID 40407985.
Tervi A, Ramste M, Abner E, Cheng P, Lane JM, Maher M, et al. (September 2024). "Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity". Cell Genomics. 4 (9) 100630. doi:10.1016/j.xgen.2024.100630. PMC 11480858. PMID 39142284.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171729 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040616 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Transmembrane protein 51". Retrieved 2012-10-29.

[AceView-6] "AceView: Gene:TMEM51, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView". www.ncbi.nlm.nih.gov. Retrieved 2025-09-29.

[7] "Homo sapiens transmembrane protein 51 (TMEM51), transcript variant 1, mRNA". NCBI. 2025-04-27.

[8] Wu D, Xia Q, Su X, Mao Y, Mao J, Ding Q, et al. (May 2025). "Long non-coding RNA TMEM51-AS1 inhibits colorectal cancer progression". Discover Oncology. 16 (1) 878. doi:10.1007/s12672-025-02676-z. PMC 12102048. PMID 40407985.

[9] Tervi A, Ramste M, Abner E, Cheng P, Lane JM, Maher M, et al. (September 2024). "Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity". Cell Genomics. 4 (9) 100630. doi:10.1016/j.xgen.2024.100630. PMC 11480858. PMID 39142284.

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