TMCO1

TMCO1
Identifiers
Aliases	TMCO1, HP10122, PCIA3, PNAS-136, TMCC4, transmembrane and coiled-coil domains 1
External IDs	OMIM: 614123; MGI: 1921173; HomoloGene: 10384; GeneCards: TMCO1; OMA:TMCO1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	165,827,755 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	167,161,547 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; Epithelium of choroid plexus; ; rectum; ; islet of Langerhans; ; jejunal mucosa; ; gallbladder; ; mucosa of colon; ; mucosa of transverse colon; ; bronchial epithelial cell; ; mucosa of sigmoid colon;
	Top expressed in
	right kidney; ; seminal vesicula; ; molar; ; parotid gland; ; left lung lobe; ; spermatocyte; ; decidua; ; submandibular gland; ; atrioventricular valve; ; human kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium channel activity;
Cellular component	membrane; endoplasmic reticulum membrane; Golgi membrane; Golgi apparatus; integral component of membrane; endoplasmic reticulum; integral component of endoplasmic reticulum membrane;
Biological process	calcium ion transport; ER overload response; ion transport; calcium ion transmembrane transport; endoplasmic reticulum calcium ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	54499
	68944
	ENSG00000143183
	ENSMUSG00000052428
	Q9UM00
	Q921L3
	NM_001256164; NM_001256165; NM_019026; NM_001366129
	NM_001039483; NM_026881
	NP_001243093; NP_001243094; NP_061899
	NP_001034572
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the TMCO1 gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000143183 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000052428 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
"Entrez Gene: TMCO1 transmembrane and coiled-coil domains 1".

Further reading

Iwamuro S, Saeki M, Kato S (1999). "Multi-ubiquitination of a nascent membrane protein produced in a rabbit reticulocyte lysate". J. Biochem. 126 (1): 48–53. doi:10.1093/oxfordjournals.jbchem.a022435. PMID 10393320.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143183 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052428 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8619474-5] Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

[pmid9110174-6] Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.

[entrez-7] "Entrez Gene: TMCO1 transmembrane and coiled-coil domains 1".

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