Article · Wikipedia archive · Last revised Jun 7, 2026

Tissue-selective estrogen complex

A tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator (SERM), such as tamoxifen, raloxifene, or bazedoxifene. It is thought to have different tissue pattern of estrogenic and antiestrogenic effects than that of either the estrogen or the SERM alone. An example of a clinically used TSEC is conjugated estrogens/bazedoxifene.

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Jun 7, 2026
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A tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator (SERM), such as tamoxifen, raloxifene, or bazedoxifene.1 It is thought to have different tissue pattern of estrogenic and antiestrogenic effects than that of either the estrogen or the SERM alone.1 An example of a clinically used TSEC is conjugated estrogens/bazedoxifene (brand name Duavee).2

References

References

  1. Pickar JH, Boucher M, Morgenstern D (September 2018). "Tissue selective estrogen complex (TSEC): a review". Menopause. 25 (9): 1033–1045. doi:10.1097/GME.0000000000001095. PMC 6110370. PMID 29533367.
  2. Lello S, Capozzi A, Scambia G (2017). "The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause". Int J Endocrinol. 2017 5064725. doi:10.1155/2017/5064725. PMC 5735652. PMID 29358948.