THRAP3

THRAP3
Identifiers
Aliases	THRAP3, TRAP150, thyroid hormone receptor associated protein 3, BCLAF2
External IDs	OMIM: 603809; MGI: 2442637; HomoloGene: 31289; GeneCards: THRAP3; OMA:THRAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	36,305,357 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	126,202,760 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; ventricular zone; ; Achilles tendon; ; ganglionic eminence; ; stromal cell of endometrium; ; muscle of thigh; ; Descending thoracic aorta; ; gastric mucosa; ; right coronary artery; ; right lobe of thyroid gland;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; neural layer of retina; ; spermatocyte; ; yolk sac; ; epiblast; ; lip; ; Rostral migratory stream; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; transcription coactivator activity; transcription coregulator activity; thyroid hormone receptor binding; phosphoprotein binding; core promoter sequence-specific DNA binding; protein binding; nuclear receptor coactivator activity; ATP binding; vitamin D receptor binding; RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; signaling receptor activity;
Cellular component	nuclear speck; mediator complex; exon-exon junction complex; nucleoplasm; extracellular exosome; nucleus;
Biological process	androgen receptor signaling pathway; regulation of transcription, DNA-templated; positive regulation of mRNA splicing, via spliceosome; rhythmic process; mRNA processing; intracellular steroid hormone receptor signaling pathway; regulation of alternative mRNA splicing, via spliceosome; transcription, DNA-templated; positive regulation of transcription, DNA-templated; nuclear-transcribed mRNA catabolic process; mRNA stabilization; circadian rhythm; RNA splicing; positive regulation of circadian rhythm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9967
	230753
	ENSG00000054118
	ENSMUSG00000043962
	Q9Y2W1
	Q569Z6
	NM_005119; NM_001321471; NM_001321473
	NM_146153; NM_001356455; NM_001356456
	NP_001308400; NP_001308402; NP_005110
	NP_666265; NP_001343384; NP_001343385
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000054118 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000043962 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: THRAP3 thyroid hormone receptor associated protein 3".

Further reading

Fondell JD, Ge H, Roeder RG (1996). "Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8329–33. Bibcode:1996PNAS...93.8329F. doi:10.1073/pnas.93.16.8329. PMC 38670. PMID 8710870.
Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature. 398 (6730): 828–32. Bibcode:1999Natur.398..828N. doi:10.1038/19789. PMID 10235267. S2CID 23646963.
Ge K, Guermah M, Yuan CX, et al. (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature. 417 (6888): 563–7. Bibcode:2002Natur.417..563G. doi:10.1038/417563a. PMID 12037571. S2CID 4432077.
Johnson KM, Wang J, Smallwood A, et al. (2002). "TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA". Genes Dev. 16 (14): 1852–63. doi:10.1101/gad.995702. PMC 186393. PMID 12130544.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000054118 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043962 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: THRAP3 thyroid hormone receptor associated protein 3".

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