THOC2

THOC2
Identifiers
Aliases	THOC2, CXorf3, THO2, dJ506G2.1, hTREX120, MRX12, MRX35, THO complex 2
External IDs	OMIM: 300395; MGI: 2442413; HomoloGene: 69669; GeneCards: THOC2; OMA:THOC2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	123,733,056 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	41,009,551 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Achilles tendon; ; sural nerve; ; ventricular zone; ; epithelium of colon; ; right lung; ; visceral pleura; ; left ovary; ; gastric mucosa; ; body of pancreas;
	Top expressed in
	Rostral migratory stream; ; sciatic nerve; ; retinal pigment epithelium; ; primitive streak; ; ciliary body; ; tail of embryo; ; medullary collecting duct; ; umbilical cord; ; vestibular membrane of cochlear duct; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; mRNA binding;
Cellular component	THO complex; nuclear speck; THO complex part of transcription export complex; transcription export complex; nucleus; nucleoplasm;
Biological process	poly(A)+ mRNA export from nucleus; mRNA processing; mRNA transport; neuron development; viral mRNA export from host cell nucleus; RNA splicing; generation of neurons; RNA export from nucleus; mRNA export from nucleus; mRNA 3'-end processing; cell morphogenesis; blastocyst development; regulation of gene expression; regulation of mRNA export from nucleus; negative regulation of neuron projection development; stem cell division;
	Sources:Amigo / QuickGO
Orthologs
	57187
	331401
	ENSG00000125676
	ENSMUSG00000037475
	Q8NI27
	B1AZI6
	NM_001081550; NM_020449
	NM_001033422
	NP_001075019
	NP_001028594
	Wikidata
View/Edit Human	View/Edit Mouse

THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene.⁵⁶

THO2 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]⁶

References

GRCh38: Ensembl release 89: ENSG00000125676 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000037475 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
"Entrez Gene: THOC2 THO complex 2".

Further reading

Coffey AJ, Brooksbank RA, Brandau O, et al. (1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene". Nat. Genet. 20 (2): 129–35. doi:10.1038/2424. PMID 9771704. S2CID 9347438.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125676 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037475 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11979277-5] Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.

[entrez-6] "Entrez Gene: THOC2 THO complex 2".

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