THOC1

THOC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WXP
Identifiers
Aliases	THOC1, HPR1, P84, P84N5, THO complex 1
External IDs	OMIM: 606930; MGI: 1919668; HomoloGene: 38012; GeneCards: THOC1; OMA:THOC1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	268,050 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	9,995,489 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right uterine tube; ; anterior pituitary; ; corpus callosum; ; left ovary; ; left lobe of thyroid gland; ; body of pancreas; ; tibial nerve;
	Top expressed in
	cumulus cell; ; spermatocyte; ; tail of embryo; ; Gonadal ridge; ; epiblast; ; external carotid artery; ; abdominal wall; ; primitive streak; ; spermatid; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA binding;
Cellular component	cytoplasm; transcription export complex; nuclear matrix; intercellular bridge; THO complex; THO complex part of transcription export complex; nucleus; nucleoplasm; cytosol; nuclear speck;
Biological process	regulation of DNA recombination; mRNA transport; RNA processing; regulation of transcription, DNA-templated; negative regulation of DNA damage checkpoint; mRNA processing; regulation of DNA-templated transcription, elongation; viral mRNA export from host cell nucleus; transcription, DNA-templated; positive regulation of DNA-templated transcription, elongation; negative regulation of isotype switching to IgA isotypes; RNA splicing; replication fork processing; signal transduction; apoptotic process; RNA export from nucleus; mRNA export from nucleus; mRNA 3'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	9984
	225160
	ENSG00000079134
	ENSMUSG00000024287
	Q96FV9
	Q8R3N6
	NM_005131
	NM_153552
	NP_005122
	NP_705780
	Wikidata
View/Edit Human	View/Edit Mouse

THO complex subunit 1 is a protein that in humans is encoded by the THOC1 gene.⁵⁶

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 606390).[supplied by OMIM]⁶

Interactions

THOC1 has been shown to interact with Retinoblastoma protein.⁷

References

GRCh38: Ensembl release 89: ENSG00000079134 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024287 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.
"Entrez Gene: THOC1 THO complex 1".
Durfee, T; Mancini M A; Jones D; Elledge S J; Lee W H (November 1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. ISSN 0021-9525. PMC 2120229. PMID 7525595.

Further reading

Durfee T, Mancini MA, Jones D, et al. (1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. PMC 2120229. PMID 7525595.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dennehey BK, Gutches DG, McConkey EH, Krauter KS (2004). "Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution". Genomics. 83 (3): 493–501. doi:10.1016/j.ygeno.2003.08.017. PMID 14962675.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gasparri F, Sola F, Locatelli G, Muzio M (2004). "The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm". FEBS Lett. 574 (1–3): 13–9. doi:10.1016/j.febslet.2004.07.074. PMID 15358532. S2CID 43023236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li Y, Wang X, Zhang X, Goodrich DW (2005). "Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors". Mol. Cell. Biol. 25 (10): 4023–33. doi:10.1128/MCB.25.10.4023-4033.2005. PMC 1087710. PMID 15870275.
Masuda S, Das R, Cheng H, et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Li Y, Lin AW, Zhang X, et al. (2007). "Cancer cells and normal cells differ in their requirements for Thoc1". Cancer Res. 67 (14): 6657–64. doi:10.1158/0008-5472.CAN-06-3234. PMC 2804983. PMID 17638875.
Garner E, Martinon F, Tschopp J, et al. (2007). "Cells with defective p53-p21-pRb pathway are susceptible to apoptosis induced by p84N5 via caspase-6". Cancer Res. 67 (16): 7631–7. doi:10.1158/0008-5472.CAN-07-0334. PMID 17699767.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079134 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024287 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11979277-5] Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (May 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. Bibcode:2002Natur.417..304S. doi:10.1038/nature746. PMID 11979277. S2CID 1112194.

[entrez-6] "Entrez Gene: THOC1 THO complex 1".

[pmid7525595-7] Durfee, T; Mancini M A; Jones D; Elledge S J; Lee W H (November 1994). "The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing". J. Cell Biol. 127 (3): 609–22. doi:10.1083/jcb.127.3.609. ISSN 0021-9525. PMC 2120229. PMID 7525595.

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