Thenalidine

Thenalidine
Clinical data
ATC code	D04AA03 (WHO) R06AX03 (WHO) ; R06AX53 (WHO) (combinations);
Identifiers
	IUPAC name 1-Methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine;
CAS Number	86-12-4 Y;
PubChem CID	27901;
DrugBank	DB04826 Y;
ChemSpider	25957 N;
UNII	6U94N2D00F;
KEGG	D07194 Y;
CompTox Dashboard (EPA)	DTXSID1048835 ;
ECHA InfoCard	100.001.501
Chemical and physical data
Formula	C17H22N2S
Molar mass	286.44 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES s1c(ccc1)CN(c2ccccc2)C3CCN(C)CC3;
	InChI InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3 N; Key:KLOHYVOVXOUKQI-UHFFFAOYSA-N N;
	NY (what is this?) (verify)

Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug.¹ It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.²

References

Clinical data

ATC code	D04AA03 (WHO) R06AX03 (WHO) R06AX53 (WHO) (combinations)
Identifiers
IUPAC name 1-Methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine
CAS Number	86-12-4^Y
PubChem CID	27901
DrugBank	DB04826^Y
ChemSpider	25957^N
UNII	6U94N2D00F
KEGG	D07194^Y
CompTox Dashboard (EPA)	DTXSID1048835
ECHA InfoCard	100.001.501
Chemical and physical data
Formula	C₁₇H₂₂N₂S
Molar mass	286.44 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES s1c(ccc1)CN(c2ccccc2)C3CCN(C)CC3
InChI InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3^N Key:KLOHYVOVXOUKQI-UHFFFAOYSA-N^N
^NY (what is this?) (verify)