SYT7

SYT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D8K
Identifiers
Aliases	SYT7, IPCA-7, IPCA7, PCANAP7, SYT-VII, SYTVII, synaptotagmin 7
External IDs	OMIM: 604146; MGI: 1859545; HomoloGene: 20889; GeneCards: SYT7; OMA:SYT7 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,581,148 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,430,544 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; prefrontal cortex; ; cerebellar vermis; ; cingulate gyrus; ; anterior cingulate cortex; ; right lobe of liver; ; pituitary gland;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; dentate gyrus; ; piriform cortex; ; substantia nigra; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; metal ion binding; protein binding; SNARE binding; syntaxin binding; clathrin binding; phosphatidylinositol-4,5-bisphosphate binding; calcium-dependent phospholipid binding; calmodulin binding; phosphatidylserine binding;
Cellular component	integral component of membrane; membrane; synapse; synaptic vesicle membrane; cell junction; terminal bouton; dense core granule; extracellular exosome; cytoplasmic vesicle; transport vesicle membrane; cytosol; synaptic vesicle; presynaptic membrane; lysosome; peroxisome; peroxisomal membrane; phagocytic vesicle membrane; plasma membrane; lysosomal membrane; early phagosome; dendrite; soma; axon terminus; axon; neuron projection; exocytic vesicle; hippocampal mossy fiber to CA3 synapse; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic membrane;
Biological process	regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; exocytosis; regulation of bone remodeling; plasma membrane repair; calcium-ion regulated exocytosis; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; regulation of glucagon secretion; phagosome-lysosome fusion; synaptic vesicle recycling; vesicle-mediated cholesterol transport; regulation of phagocytosis; vesicle fusion; calcium ion regulated lysosome exocytosis; phagocytosis; regulation of dopamine secretion; short-term synaptic potentiation; vesicle-mediated transport; cellular response to calcium ion; calcium-dependent activation of synaptic vesicle fusion; regulation of synaptic vesicle endocytosis;
	Sources:Amigo / QuickGO
Orthologs
	9066
	54525
	ENSG00000011347
	ENSMUSG00000024743
	O43581
	Q9R0N7
NM_001252065; NM_001300773; NM_004200; NM_001365809; NM_001370210;
	NM_001370211
	NM_018801; NM_173067; NM_173068; NM_001373944
NP_001238994; NP_001287702; NP_004191; NP_001352738; NP_001357139;
	NP_001357140
	NP_061271; NP_775090; NP_775091
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.⁵⁶

Function

Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM]⁶

Interactions

SYT7 has been shown to interact with SYNCRIP.⁷

References

GRCh38: Ensembl release 89: ENSG00000011347 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024743 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.
"Entrez Gene: SYT7 synaptotagmin VII".
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

External links

Overview of all the structural information available in the PDB for UniProt: O43581 (Human Synaptotagmin-7) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q9R0N7 (Mouse Synaptotagmin-7) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011347 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024743 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9615227-5] Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. doi:10.1006/geno.1998.5291. PMID 9615227.

[entrez-6] "Entrez Gene: SYT7 synaptotagmin VII".

[pmid10734137-7] Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

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Function

Interactions

References

Further reading

External links