SYT2

SYT2
Identifiers
Aliases	SYT2, SytII, CMS7, MYSPC, synaptotagmin 2, CMS7A, CMS7B
External IDs	OMIM: 600104; MGI: 99666; HomoloGene: 22516; GeneCards: SYT2; OMA:SYT2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,710,454 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,690,331 bp
RNA expression pattern
	Top expressed in
	pons; ; external globus pallidus; ; paraflocculus of cerebellum; ; cerebellar vermis; ; lateral nuclear group of thalamus; ; right hemisphere of cerebellum; ; superior vestibular nucleus; ; pars compacta; ; dorsal motor nucleus of vagus nerve; ; pars reticulata;
	Top expressed in
	cerebellar cortex; ; inferior colliculi; ; medulla oblongata; ; deep cerebellar nuclei; ; pontine nuclei; ; medial vestibular nucleus; ; facial motor nucleus; ; anterior horn of spinal cord; ; cerebellar vermis; ; lobe of cerebellum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; inositol 1,3,4,5 tetrakisphosphate binding; clathrin binding; syntaxin binding; protein binding; calcium-dependent phospholipid binding; SNARE binding; phosphatidylserine binding;
Cellular component	cell junction; chromaffin granule membrane; synaptic vesicle; membrane; cytoplasmic vesicle; synapse; integral component of membrane; synaptic vesicle membrane; plasma membrane; clathrin-coated vesicle membrane; axon; dense core granule; exocytic vesicle;
Biological process	synaptic vesicle endocytosis; cell differentiation; neurotransmitter secretion; positive regulation of dendrite extension; vesicle fusion; regulation of calcium ion-dependent exocytosis; calcium ion-regulated exocytosis of neurotransmitter; membrane organization; regulation of dopamine secretion; synaptic vesicle exocytosis; vesicle-mediated transport; calcium-ion regulated exocytosis; cellular response to calcium ion;
	Sources:Amigo / QuickGO
Orthologs
	127833
	20980
	ENSG00000143858
	ENSMUSG00000026452
	Q8N9I0
	P46097
	NM_001136504; NM_177402
	NM_009307; NM_001355726
	NP_001129976; NP_796376
	NP_033333; NP_001342655
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026452 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.
"Entrez Gene: SYT2 synaptotagmin II".

Further reading

Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K (November 1994). "Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II". The Journal of Biological Chemistry. 269 (46): 29206–11. doi:10.1016/S0021-9258(19)62031-4. PMID 7961887.
Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.
Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R (May 1999). "Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells". The Journal of Experimental Medicine. 189 (10): 1649–58. doi:10.1084/jem.189.10.1649. PMC 2193646. PMID 10330444.
Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (August 2000). "Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum". The Journal of Cell Biology. 150 (4): 719–30. doi:10.1083/jcb.150.4.719. PMC 2175286. PMID 10952998.
Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS (May 2001). "Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery". The Journal of Cell Biology. 153 (5): 1111–20. doi:10.1083/jcb.153.5.1111. PMC 2174325. PMID 11381094.
Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K (November 2001). "Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II". FEBS Letters. 507 (3): 341–5. doi:10.1016/S0014-5793(01)03000-9. PMID 11696368. S2CID 29026112.
Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O (June 2002). "Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1590 (1–3): 159–66. doi:10.1016/S0167-4889(02)00209-4. PMID 12063179.
Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B (March 2004). "Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate". The Journal of Biological Chemistry. 279 (13): 12574–9. doi:10.1074/jbc.M310710200. PMID 14709554.
Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH (September 2004). "WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding". Molecular Cell. 15 (5): 741–51. doi:10.1016/j.molcel.2004.07.018. PMID 15350218.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143858 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026452 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7749232-5] Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. hdl:2027.42/47020. PMID 7749232. S2CID 24653745.

[entrez-6] "Entrez Gene: SYT2 synaptotagmin II".

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