Syntaxin binding protein 3

STXBP3
Identifiers
Aliases	STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3
External IDs	OMIM: 608339; MGI: 107362; HomoloGene: 5260; GeneCards: STXBP3; OMA:STXBP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	108,809,523 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,747,842 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; tibia; ; C1 segment; ; germinal epithelium; ; epithelium of nasopharynx; ; inferior ganglion of vagus nerve; ; monocyte; ; sural nerve; ; palpebral conjunctiva;
	Top expressed in
	skin of external ear; ; stroma of bone marrow; ; Epithelium of choroid plexus; ; ascending aorta; ; sciatic nerve; ; jejunum; ; aortic valve; ; retinal pigment epithelium; ; transitional epithelium of urinary bladder; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin-1 binding; protein binding; syntaxin binding;
Cellular component	cytoplasm; platelet alpha granule; cytosol; membrane; tertiary granule; plasma membrane; basolateral plasma membrane; specific granule; apical plasma membrane; extracellular exosome; phagocytic vesicle; presynapse;
Biological process	protein to membrane docking; protein heterooligomerization; neutrophil degranulation; insulin secretion; vesicle docking involved in exocytosis; response to insulin; brain development; negative regulation of calcium ion-dependent exocytosis; protein transport; platelet aggregation; vesicle-mediated transport; exocytosis; transport; cellular glucose homeostasis; negative regulation of glucose import; cellular response to interferon-gamma;
	Sources:Amigo / QuickGO
Orthologs
	6814
	20912
	ENSG00000116266
	ENSMUSG00000027882
	O00186
	Q60770
	NM_007269
	NM_011504
	NP_009200
	NP_035634
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.⁵⁶

Interactions

Syntaxin binding protein 3 has been shown to interact with STX2⁷ and STX4.⁷⁸

References

GRCh38: Ensembl release 89: ENSG00000116266 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027882 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. doi:10.1182/blood.V93.8.2617. PMID 10194441.
"Entrez Gene: STXBP3 syntaxin binding protein 3".
Schraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

Further reading

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (November 1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants". The Journal of Neuroscience. 16 (21): 6695–702. doi:10.1523/JNEUROSCI.16-21-06695.1996. PMC 6579271. PMID 8824310.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (August 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Fu J, Naren AP, Gao X, Ahmmed GU, Malik AB (February 2005). "Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression". The Journal of Biological Chemistry. 280 (5): 3178–84. doi:10.1074/jbc.M410044200. PMID 15576373.
Hodgkinson CP, Mander A, Sale GJ (June 2005). "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking". The Biochemical Journal. 388 (Pt 3): 785–93. doi:10.1042/BJ20041845. PMC 1183457. PMID 15707389.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116266 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027882 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10194441-5] Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. doi:10.1182/blood.V93.8.2617. PMID 10194441.

[entrez-6] "Entrez Gene: STXBP3 syntaxin binding protein 3".

[pmid12773094-7] Schraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.

[pmid12832401-8] Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

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