SUGT1

SUGT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RL1
Identifiers
Aliases	SUGT1, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
External IDs	OMIM: 604098; MGI: 1915205; HomoloGene: 4877; GeneCards: SUGT1; OMA:SUGT1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	52,700,909 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	79,872,636 bp
RNA expression pattern
	Top expressed in
	cardiac muscle tissue of right atrium; ; pancreatic epithelial cell; ; myocardium of left ventricle; ; oocyte; ; cartilage tissue; ; parietal pleura; ; tibia; ; pancreatic ductal cell; ; gingival epithelium; ; tendon of biceps brachii;
	Top expressed in
	morula; ; morula; ; blastocyst; ; otic vesicle; ; medial ganglionic eminence; ; abdominal wall; ; epiblast; ; superior surface of tongue; ; otic placode; ; spermatid;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; nucleus; kinetochore; ubiquitin ligase complex; protein-containing complex;
Biological process	regulation of protein stability; mitotic cell cycle; protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	10910
	67955
	ENSG00000165416
	ENSMUSG00000022024
	Q9Y2Z0
	Q9CX34
	NM_001130912; NM_006704; NM_001320831
	NM_026474
	NP_001124384; NP_001307760; NP_006695
	NP_080750
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.⁵⁶

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.⁶

Interactions

SUGT1 has been shown to interact with S100A6.⁷

References

GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.
"Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".
Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.

Further reading

Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.
Niikura Y, Kitagawa K (December 2003). "Identification of a novel splice variant: human SGT1B (SUGT1B)". DNA Sequence. 14 (6): 436–41. doi:10.1080/10425170310001623644. PMID 15018354. S2CID 20578581.
Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y (April 2004). "Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1". DNA Sequence. 15 (2): 140–3. doi:10.1080/1042517032000160215. PMID 15346769. S2CID 37324928.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
da Silva Correia J, Miranda Y, Leonard N, Ulevitch R (April 2007). "SGT1 is essential for Nod1 activation". Proceedings of the National Academy of Sciences of the United States of America. 104 (16): 6764–9. Bibcode:2007PNAS..104.6764D. doi:10.1073/pnas.0610926104. PMC 1871859. PMID 17420470.
Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A (June 2007). "Hsp70 is a new target of Sgt1--an interaction modulated by S100A6". Biochemical and Biophysical Research Communications. 357 (4): 1148–53. doi:10.1016/j.bbrc.2007.04.073. PMID 17466273.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165416 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022024 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10445024-5] Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P (July 1999). "SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex". Molecular Cell. 4 (1): 21–33. doi:10.1016/S1097-2765(00)80184-7. PMID 10445024.

[entrez-6] "Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)".

[pmid12746458-7] Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J (July 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". The Journal of Biological Chemistry. 278 (29): 26923–8. doi:10.1074/jbc.M211518200. PMID 12746458.

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