Article · Wikipedia archive · Last revised Jun 27, 2026

Stattic

Stattic is a drug that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer and autoimmune disorders.

Last revised
Jun 27, 2026
Read time
≈ 1 min
Length
152 w
Citations
3
Source
Wikipedia ↗
Stattic
Clinical data
Drug classSTAT3 inhibitor
Identifiers
  • 6-nitro-1-benzothiophene 1,1-dioxide
CAS Number
PubChem CID
ChemSpider
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H5NO4S
Molar mass211.19 g·mol−1
3D model (JSmol)
  • C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
  • InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
  • Key:ZRRGOUHITGRLBA-UHFFFAOYSA-N

Stattic is a drug that acts as an inhibitor of the transcription factor protein STAT3. It has potential applications in the treatment of cancer and autoimmune disorders.123

References

References

  1. Ko HJ, Kim YJ (November 2016). "Signal transducer and activator of transcription proteins: regulators of myeloid-derived suppressor cell-mediated immunosuppression in cancer". Archives of Pharmacal Research. 39 (11): 1597–1608. doi:10.1007/s12272-016-0822-9. PMID 27572156.
  2. Samad MA, Ahmad I, Hasan A, Alhashmi MH, Ayub A, Al-Abbasi FA, et al. (April 2025). "STAT3 Signaling Pathway in Health and Disease". MedComm. 6 (4) e70152. doi:10.1002/mco2.70152. PMC 11955304. PMID 40166646.
  3. Wu Z, Lian G, He L, Hu P, Guo Y, Su Z (January 2026). "Targeting JAK-STAT signaling for autoimmune diseases: current understanding, clinical advances, and emerging directions". Immunology and Cell Biology imcb.70078. doi:10.1111/imcb.70078. PMID 41517955.