ST3GAL4

ST3GAL4
Identifiers
Aliases	ST3GAL4, CGS23, NANTA3, SAT3, SIAT4, SIAT4C, ST3GalIV, STZ, ST3 beta-galactoside alpha-2,3-sialyltransferase 4, ST-4, gal-NAc6S, ST3GalA.2
External IDs	OMIM: 104240; MGI: 1316743; HomoloGene: 4572; GeneCards: ST3GAL4; OMA:ST3GAL4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	126,440,344 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	35,030,564 bp
RNA expression pattern
	Top expressed in
	left adrenal cortex; ; right adrenal cortex; ; left ovary; ; right ovary; ; rectum; ; C1 segment; ; right auricle of heart; ; tibial nerve; ; transverse colon; ; right testis;
	Top expressed in
	Ileal epithelium; ; jejunum; ; gallbladder; ; crypt of lieberkuhn of small intestine; ; molar; ; granulocyte; ; parotid gland; ; submandibular gland; ; duodenum; ; liver;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; sialyltransferase activity; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity; monosialoganglioside sialyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; Golgi cisterna membrane; extracellular region; extracellular exosome; membrane; Golgi membrane;
Biological process	cognition; O-glycan processing; keratan sulfate biosynthetic process; oligosaccharide metabolic process; protein N-linked glycosylation via asparagine; protein glycosylation; glycoprotein biosynthetic process; glycolipid biosynthetic process; oligosaccharide biosynthetic process; lipid glycosylation; sialylation; protein sialylation;
	Sources:Amigo / QuickGO
Orthologs
	6484
	20443
	ENSG00000110080
	ENSMUSG00000032038
	Q11206
	Q91Y74
NM_001254757; NM_001254758; NM_001254759; NM_006278; NM_001348396;
	NM_001348398; NM_001348399; NM_001348400; NM_001348397
	NM_009178
NP_001241686; NP_001241687; NP_001241688; NP_006269; NP_001335325;
	NP_001335327; NP_001335328; NP_001335329; NP_001335326
	NP_033204
	Wikidata
View/Edit Human	View/Edit Mouse

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000110080 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032038 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kitagawa H, Mattei MG, Paulson JC (Feb 1996). "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase". J Biol Chem. 271 (2): 931–8. doi:10.1074/jbc.271.2.931. PMID 8557707.
Kitagawa H, Paulson JC (Feb 1994). "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups". J Biol Chem. 269 (2): 1394–401. doi:10.1016/S0021-9258(17)42271-X. PMID 8288606.
"Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4".

Further reading

Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Munro S (1995). "An investigation of the role of transmembrane domains in Golgi protein retention". EMBO J. 14 (19): 4695–704. doi:10.1002/j.1460-2075.1995.tb00151.x. PMC 394566. PMID 7588599.
Chang ML, Eddy RL, Shows TB, Lau JT (1995). "Three genes that encode human beta-galactoside alpha 2,3-sialyltransferases. Structural analysis and chromosomal mapping studies". Glycobiology. 5 (3): 319–25. doi:10.1093/glycob/5.3.319. PMID 7655169.
Sasaki K, Watanabe E, Kawashima K, et al. (1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J. Biol. Chem. 268 (30): 22782–7. doi:10.1016/S0021-9258(18)41595-5. PMID 7901202.
Basu SS, Basu M, Li Z, Basu S (1996). "Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line". Biochemistry. 35 (16): 5166–74. doi:10.1021/bi960239l. PMID 8611500.
Saito S, Yamashita S, Endoh M, et al. (2003). "Clinical significance of ST3Gal IV expression in human renal cell carcinoma". Oncol. Rep. 9 (6): 1251–5. doi:10.3892/or.9.6.1251. PMID 12375029.
Grahn A, Larson G (2003). "Identification of nine alternatively spliced alpha2,3-sialyltransferase, ST3Gal IV, transcripts and analysis of their expression by RT-PCR and laser-induced fluorescent capillary electrophoresis (LIF-CE) in twenty-one human tissues". Glycoconj. J. 18 (10): 759–67. doi:10.1023/A:1021199300718. PMID 12441665. S2CID 11260655.
Moody AM, North SJ, Reinhold B, et al. (2003). "Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction". J. Biol. Chem. 278 (9): 7240–6. doi:10.1074/jbc.M210468200. PMID 12459555.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Taniguchi A, Hioki M, Matsumoto K (2003). "Transcriptional regulation of human Galbeta1,3GalNAc/Galbeta1, 4GlcNAc alpha2,3-sialyltransferase (hST3Gal IV) gene in testis and ovary cell lines". Biochem. Biophys. Res. Commun. 301 (3): 764–8. doi:10.1016/S0006-291X(03)00041-X. PMID 12565846.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi:10.1016/j.febslet.2006.09.073. PMID 17054948. S2CID 9731951.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110080 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032038 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8557707-5] Kitagawa H, Mattei MG, Paulson JC (Feb 1996). "Genomic organization and chromosomal mapping of the Gal beta 1,3GalNAc/Gal beta 1,4GlcNAc alpha 2,3-sialyltransferase". J Biol Chem. 271 (2): 931–8. doi:10.1074/jbc.271.2.931. PMID 8557707.

[pmid8288606-6] Kitagawa H, Paulson JC (Feb 1994). "Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups". J Biol Chem. 269 (2): 1394–401. doi:10.1016/S0021-9258(17)42271-X. PMID 8288606.

[entrez-7] "Entrez Gene: ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4".

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