SRRM1

SRRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MP1
Identifiers
Aliases	SRRM1, 160-KD, POP101, SRM160, serine and arginine repetitive matrix 1
External IDs	OMIM: 605975; MGI: 1858303; HomoloGene: 136796; GeneCards: SRRM1; OMA:SRRM1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	24,673,267 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	135,353,321 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; sural nerve; ; caput epididymis; ; right uterine tube; ; left ovary; ; buccal mucosa cell; ; right ovary; ; body of uterus; ; tail of epididymis; ; right hemisphere of cerebellum;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primitive streak; ; Paneth cell; ; abdominal wall; ; neural layer of retina; ; ciliary body; ; Ileal epithelium; ; zygote; ; cumulus cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; RNA binding;
Cellular component	nuclear matrix; cytosol; catalytic step 2 spliceosome; spliceosomal complex; nucleus; nucleoplasm; nuclear speck;
Biological process	RNA splicing, via transesterification reactions; mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; mRNA export from nucleus; RNA splicing; RNA export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
	10250
	51796
	ENSG00000133226
	ENSMUSG00000028809
	Q8IYB3
	Q52KI8
	NM_001303448; NM_001303449; NM_005839
NM_001130477; NM_016799; NM_001369067; NM_001369068; NM_001369069;
	NM_001369070; NM_001369071; NM_001369072; NM_001369073; NM_001369074
NP_001290377; NP_001290378; NP_005830; NP_001353494; NP_001353495;
	NP_001353496; NP_001353497; NP_001353498; NP_001353499; NP_001353500; NP_001353501; NP_001353502; NP_001353504; NP_001353505; NP_001353506; NP_001353507; NP_001353510; NP_001353511; NP_001353513; NP_001353514; NP_001353515; NP_001353516; NP_001353517; NP_001353518; NP_001353519; NP_001353520; NP_001353521; NP_001353522; NP_001353523; NP_001353524; NP_001353525; NP_001353526; NP_001353527; NP_001353528; NP_001353529
NP_001123949; NP_058079; NP_001355996; NP_001355997; NP_001355998;
	NP_001355999; NP_001356000; NP_001356001; NP_001356002; NP_001356003
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.⁵⁶

Interactions

SRRM1 has been shown to interact with CDC5L.⁷

References

GRCh38: Ensembl release 89: ENSG00000133226 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028809 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
"Entrez Gene: SRRM1 serine/arginine repetitive matrix 1".
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Further reading

Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028.
Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA (1999). "The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction". J. Biol. Chem. 274 (7): 4166–73. doi:10.1074/jbc.274.7.4166. PMID 9933612.
Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA (2000). "The SRm160/300 splicing coactivator subunits". RNA. 6 (1): 111–20. doi:10.1017/S1355838200991982. PMC 1369899. PMID 10668804.
Le Hir H, Moore MJ, Maquat LE (2000). "Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions". Genes Dev. 14 (9): 1098–108. doi:10.1101/gad.14.9.1098. PMC 316578. PMID 10809668.
McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ (2000). "The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes". J. Cell Biol. 150 (2): 309–20. doi:10.1083/jcb.150.2.309. PMC 2180225. PMID 10908574.
Le Hir H, Izaurralde E, Maquat LE, Moore MJ (2000). "The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions". EMBO J. 19 (24): 6860–9. doi:10.1093/emboj/19.24.6860. PMC 305905. PMID 11118221.
Lykke-Andersen J, Shu MD, Steitz JA (2001). "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1". Science. 293 (5536): 1836–9. Bibcode:2001Sci...293.1836L. doi:10.1126/science.1062786. PMID 11546874. S2CID 389385.
McCracken S, Lambermon M, Blencowe BJ (2002). "SRm160 splicing coactivator promotes transcript 3'-end cleavage". Mol. Cell. Biol. 22 (1): 148–60. doi:10.1128/MCB.22.1.148-160.2002. PMC 134228. PMID 11739730.
Szymczyna BR, Pineda-Lucena A, Mills JL, Szyperski T, Arrowsmith CH (2002). "1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR". J. Biomol. NMR. 22 (3): 299–300. doi:10.1023/A:1014904502424. PMID 11991360. S2CID 13594831.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Lejeune F, Ishigaki Y, Li X, Maquat LE (2002). "The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling". EMBO J. 21 (13): 3536–45. doi:10.1093/emboj/cdf345. PMC 126094. PMID 12093754.
Meissner M, Lopato S, Gotzmann J, Sauermann G, Barta A (2003). "Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins". Exp. Cell Res. 283 (2): 184–95. doi:10.1016/S0014-4827(02)00046-0. PMID 12581738.
Szymczyna BR, Bowman J, McCracken S, Pineda-Lucena A, Lu Y, Cox B, Lambermon M, Graveley BR, Arrowsmith CH, Blencowe BJ (2003). "Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing". Genes Dev. 17 (4): 461–75. doi:10.1101/gad.1060403. PMC 196000. PMID 12600940.
Wagner S, Chiosea S, Nickerson JA (2003). "The spatial targeting and nuclear matrix binding domains of SRm160". Proc. Natl. Acad. Sci. U.S.A. 100 (6): 3269–74. Bibcode:2003PNAS..100.3269W. doi:10.1073/pnas.0438055100. PMC 152281. PMID 12624182.
McCracken S, Longman D, Johnstone IL, Cáceres JF, Blencowe BJ (2003). "An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation". J. Biol. Chem. 278 (45): 44153–60. doi:10.1074/jbc.M306856200. PMID 12944400.
Wagner S, Chiosea S, Ivshina M, Nickerson JA (2004). "In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160". J. Cell Biol. 164 (6): 843–50. doi:10.1083/jcb.200307002. PMC 2172284. PMID 15024032.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.

External links

SRRM1 human gene location in the UCSC Genome Browser.
SRRM1 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133226 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028809 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9531537-5] Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.

[entrez-6] "Entrez Gene: SRRM1 serine/arginine repetitive matrix 1".

[pmid11101529-7] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

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