SPZ1

SPZ1
Identifiers
Aliases	SPZ1, NYD-TSP1, PPP1R148, spermatogenic leucine zipper 1, CILD38
External IDs	OMIM: 618068; MGI: 1930801; HomoloGene: 49934; GeneCards: SPZ1; OMA:SPZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	80,321,842 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	92,712,680 bp
RNA expression pattern
	Top expressed in
	sperm; ; testicle; ; left testis; ; right testis; ; gonad; ; tail of epididymis; ; endometrium; ; human musculoskeletal system; ; muscular system; ; gallbladder;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; morula; ; zygote; ; islet of Langerhans; ; white adipose tissue; ; epididymis; ; striated muscle tissue; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; DNA-binding transcription factor activity;
Cellular component	cytoplasm; nucleus;
Biological process	transcription, DNA-templated; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	84654
	79401
	ENSG00000164299
	ENSMUSG00000046957
	Q9BXG8
	Q99MY0
	NM_032567
	NM_030237
	NP_115956
	NP_084513
	Wikidata
View/Edit Human	View/Edit Mouse

Spermatogenic leucine zipper protein 1 is a protein that in humans is encoded by the SPZ1 gene.⁵⁶⁷⁸⁹¹⁰

References

GRCh38: Ensembl release 89: ENSG00000164299 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000046957 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476. S2CID 17206805.
Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID 12778315.
Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.
Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.
Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (May 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.
"Entrez Gene: SPZ1 spermatogenic leucine zipper 1".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5" (PDF). Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022. S2CID 4373053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164299 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046957 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11165476-5] Hsu SH, Shyu HW, Hsieh-Li HM, Li H (Feb 2001). "Spz1, a novel bHLH-Zip protein, is specifically expressed in testis". Mech Dev. 100 (2): 177–87. doi:10.1016/S0925-4773(00)00513-X. PMID 11165476. S2CID 17206805.

[pmid12778315-6] Sha JH, Zhou ZM, Li JM, Lin M, Zhu H, Zhu H, Zhou YD, Wang LL, Wang YQ, Zhou KY (Jun 2003). "Expression of a novel bHLH-Zip gene in human testis". Asian J Androl. 5 (2): 83–8. PMID 12778315.

[pmid15226296-7] Hrabchak C, Varmuza S (Aug 2004). "Identification of the spermatogenic zip protein Spz1 as a putative protein phosphatase-1 (PP1) regulatory protein that specifically binds the PP1cgamma2 splice variant in mouse testis". J Biol Chem. 279 (35): 37079–86. doi:10.1074/jbc.M403710200. PMID 15226296.

[pmid15829580-8] Horowitz E, Zhang Z, Jones BH, Moss SB, Ho C, Wood JR, Wang X, Sammel MD, Strauss JF 3rd (Apr 2005). "Patterns of expression of sperm flagellar genes: early expression of genes encoding axonemal proteins during the spermatogenic cycle and shared features of promoters of genes encoding central apparatus proteins". Mol Hum Reprod. 11 (4): 307–17. doi:10.1093/molehr/gah163. PMID 15829580.

[pmid15899793-9] Hsu SH, Hsieh-Li HM, Huang HY, Huang PH, Li H (May 2005). "bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis". Cancer Res. 65 (10): 4041–50. doi:10.1158/0008-5472.CAN-04-3658. PMID 15899793.

[entrez-10] "Entrez Gene: SPZ1 spermatogenic leucine zipper 1".

1

2

3

4

5

6

7

8

9

10