SPRY3

SPRY3
Identifiers
Aliases	SPRY3, Hspry-3, Gm1409, Gm391, sprouty3, Spry3, sprouty RTK signaling antagonist 3
External IDs	OMIM: 300531; MGI: 1345188; HomoloGene: 4265; GeneCards: SPRY3; OMA:SPRY3 - orthologs
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; bone marrow cell; ; prefrontal cortex; ; gastrocnemius muscle; ; stromal cell of endometrium; ; left adrenal gland; ; smooth muscle tissue; ; deltoid muscle; ; monocyte; ; ascending aorta;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	cytoplasm; membrane; cytosol;
Biological process	regulation of signal transduction; axon development; multicellular organism development; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10251
	236576
	n/a
	ENSMUSG00000061654
	O43610
	Q3UUD2
	NM_001304990; NM_005840; NM_001394353; NM_001394354; NM_001394355
	NM_001030293
	NP_001291919; NP_005831
	NP_001025464; NP_001388778; NP_001388779; NP_001388780
	Wikidata
View/Edit Human	View/Edit Mouse

Protein sprouty homolog 3 is a protein that in humans is encoded by the SPRY3 gene.³⁴

The SPRY3 gene is one of the genes found in the pseudoautosomal regions of the human sex chromosomes (i.e. those 19 genes that are found on both the X and Y chromosome). It is located in the PAR2 region.

References

"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (Feb 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049.
"Entrez Gene: SPRY3 sprouty homolog 3 (Drosophila)".

Further reading

Ciccodicola A, D'Esposito M, Esposito T, et al. (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
Lim J, Wong ES, Ong SH, et al. (2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain". J. Biol. Chem. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
Lim J, Yusoff P, Wong ES, et al. (2002). "The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes". Mol. Cell. Biol. 22 (22): 7953–66. doi:10.1128/MCB.22.22.7953-7966.2002. PMC 134720. PMID 12391162.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Anteby EY, Natanson-Yaron S, Greenfield C, et al. (2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching". Placenta. 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
De Bonis ML, Cerase A, Matarazzo MR, et al. (2006). "Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications". Hum. Mol. Genet. 15 (7): 1123–32. doi:10.1093/hmg/ddl027. PMID 16500999.
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.

External links

SPRY3 human gene location in the UCSC Genome Browser.
SPRY3 human gene details in the UCSC Genome Browser.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9458049-3] Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA (Feb 1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways". Cell. 92 (2): 253–63. doi:10.1016/S0092-8674(00)80919-8. PMID 9458049.

[entrez-4] "Entrez Gene: SPRY3 sprouty homolog 3 (Drosophila)".

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