SPC24

SPC24
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VE7, 3IZ0
Identifiers
Aliases	SPC24, SPBC24, NDC80 kinetochore complex component, SPC24 component of NDC80 kinetochore complex
External IDs	OMIM: 609394; MGI: 1914879; HomoloGene: 12166; GeneCards: SPC24; OMA:SPC24 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,155,808 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,671,599 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; stromal cell of endometrium; ; trabecular bone; ; testicle; ; bone marrow; ; gonad; ; mucosa of transverse colon; ; bone marrow cell; ; appendix;
	Top expressed in
	hand; ; yolk sac; ; embryo; ; embryo; ; epiblast; ; ventricular zone; ; thymus; ; morula; ; primitive streak; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; Ndc80 complex; nucleolus; chromosome, centromeric region; nucleus; kinetochore; chromosome;
Biological process	cell division; cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	147841
	67629
	ENSG00000161888
	ENSMUSG00000074476
	Q8NBT2
	Q9D083
	NM_182513; NM_001317031; NM_001317032; NM_001317033
	NM_026282; NM_001357331
	NP_001303960; NP_001303961; NP_001303962; NP_872319
	NP_080558; NP_001344260
	Wikidata
View/Edit Human	View/Edit Mouse

Kinetochore protein Spc24 is a protein that in humans is encoded by the SPC24 gene.⁵

References

GRCh38: Ensembl release 89: ENSG00000161888 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000074476 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading

Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ (June 2005). "Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores". Current Biology. 15 (12): 1078–89. doi:10.1016/j.cub.2005.05.026. PMID 15964272. S2CID 14251198.
Ciferri C, De Luca J, Monzani S, Ferrari KJ, Ristic D, Wyman C, Stark H, Kilmartin J, Salmon ED, Musacchio A (August 2005). "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore". The Journal of Biological Chemistry. 280 (32): 29088–95. doi:10.1074/jbc.M504070200. PMID 15961401.
Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A (September 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes & Development. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMC 517519. PMID 15371340.
McCleland ML, Kallio MJ, Barrett-Wilt GA, Kestner CA, Shabanowitz J, Hunt DF, Gorbsky GJ, Stukenberg PT (January 2004). "The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment". Current Biology. 14 (2): 131–7. doi:10.1016/j.cub.2003.12.058. PMID 14738735. S2CID 16533093.
Bharadwaj R, Qi W, Yu H (March 2004). "Identification of two novel components of the human NDC80 kinetochore complex". The Journal of Biological Chemistry. 279 (13): 13076–85. doi:10.1074/jbc.M310224200. PMID 14699129.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161888 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074476 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

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