Small nuclear ribonucleoprotein polypeptide F

SNRPF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPF, SMF, Sm-F, snRNP-F, Small nuclear ribonucleoprotein polypeptide F
External IDs	OMIM: 603541; MGI: 1917128; HomoloGene: 130366; GeneCards: SNRPF; OMA:SNRPF - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	95,903,828 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	93,425,568 bp
RNA expression pattern
	Top expressed in
	oocyte; ; embryo; ; ganglionic eminence; ; epithelium of colon; ; ventricular zone; ; mucosa of pharynx; ; bone marrow; ; mucosa of transverse colon; ; oral cavity; ; pericardium;
	Top expressed in
	yolk sac; ; embryo; ; embryo; ; epiblast; ; ventricular zone; ; ganglionic eminence; ; lens; ; zygote; ; neural tube; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	U4 snRNP; SMN-Sm protein complex; pICln-Sm protein complex; nucleus; U7 snRNP; catalytic step 2 spliceosome; U1 snRNP; cytoplasm; sno(s)RNA-containing ribonucleoprotein complex; nucleoplasm; small nuclear ribonucleoprotein complex; U12-type spliceosomal complex; methylosome; cytosol; spliceosomal complex; U2-type catalytic step 2 spliceosome; U4/U6 x U5 tri-snRNP complex; U2-type precatalytic spliceosome;
Biological process	termination of RNA polymerase II transcription; histone mRNA metabolic process; mRNA processing; mRNA splicing, via spliceosome; RNA splicing; import into nucleus; spliceosomal snRNP assembly;
	Sources:Amigo / QuickGO
Orthologs
	6636
	69878
	ENSG00000139343
	ENSMUSG00000020018
	P62306
	P62307
	NM_003095; NM_001394209
	NM_027246
	NP_003086
	NP_081522
	Wikidata
View/Edit Human	View/Edit Mouse

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.⁵⁶

Interactions

Small nuclear ribonucleoprotein polypeptide F has been shown to interact with DDX20,⁷ Small nuclear ribonucleoprotein D2⁸ and Small nuclear ribonucleoprotein polypeptide E.⁸

References

GRCh38: Ensembl release 89: ENSG00000139343 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020018 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (May 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". The EMBO Journal. 14 (9): 2076–88. doi:10.1002/j.1460-2075.1995.tb07199.x. PMC 398308. PMID 7744013.
"Entrez Gene: SNRPF small nuclear ribonucleoprotein polypeptide F".
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.

Further reading

Sauterer RA, Goyal A, Zieve GW (January 1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". The Journal of Biological Chemistry. 265 (2): 1048–58. doi:10.1016/S0021-9258(19)40157-9. PMID 1688550.
Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (April 1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". The Journal of Biological Chemistry. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
Woppmann A, Rinke J, Lührmann R (December 1988). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Research. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Plessel G, Lührmann R, Kastner B (January 1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
Bühler D, Raker V, Lührmann R, Fischer U (December 1999). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Human Molecular Genetics. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (January 2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". The Journal of Biological Chemistry. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (June 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (June 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139343 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020018 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7744013-5] Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (May 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". The EMBO Journal. 14 (9): 2076–88. doi:10.1002/j.1460-2075.1995.tb07199.x. PMC 398308. PMID 7744013.

[entrez-6] "Entrez Gene: SNRPF small nuclear ribonucleoprotein polypeptide F".

[pmid10601333-7] Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.

[pmid9417867-8] Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.

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