SNAPC1

SNAPC1
Identifiers
Aliases	SNAPC1, PTFgamma, SNAP43, small nuclear RNA activating complex polypeptide 1
External IDs	OMIM: 600591; MGI: 1922877; HomoloGene: 2317; GeneCards: SNAPC1; OMA:SNAPC1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	61,796,428 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	74,035,740 bp
RNA expression pattern
	Top expressed in
	testicle; ; cartilage tissue; ; oocyte; ; secondary oocyte; ; sperm; ; bronchial epithelial cell; ; Achilles tendon; ; tail of epididymis; ; caput epididymis; ; mucosa of paranasal sinus;
	Top expressed in
	otolith organ; ; utricle; ; supraoptic nucleus; ; zygote; ; secondary oocyte; ; pituitary gland; ; hand; ; neural layer of retina; ; paraventricular nucleus of hypothalamus; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding;
Cellular component	snRNA-activating protein complex; nucleus; nucleoplasm; nucleolus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; snRNA transcription by RNA polymerase III; snRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	6617
	75627
	ENSG00000023608
	ENSMUSG00000021113
	Q16533
	Q8K0S9
	NM_003082
	NM_178392
	NP_003073
	NP_848479
	Wikidata
View/Edit Human	View/Edit Mouse

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.⁵⁶

Interactions

SNAPC1 has been shown to interact with SNAPC4,⁷ SNAPC3⁷⁸ and Retinoblastoma protein.⁹

References

GRCh38: Ensembl release 89: ENSG00000023608 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021113 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Maeng JH, Yoon JB (September 1998). "The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR". J Biochem. 124 (1): 23–7. doi:10.1093/oxfordjournals.jbchem.a022085. PMID 9644240.
"Entrez Gene: SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa".
Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. 276 (7). United States: 5027–35. doi:10.1074/jbc.M009301200. ISSN 0021-9258. PMID 11056176.
Henry RW, Ma B, Sadowski C L, Kobayashi R, Hernandez N (Dec 1996). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. 15 (24). ENGLAND: 7129–36. doi:10.1002/j.1460-2075.1996.tb01104.x. ISSN 0261-4189. PMC 452539. PMID 9003788.
Hirsch HA, Gu L, Henry R W (Dec 2000). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. 20 (24). UNITED STATES: 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. ISSN 0270-7306. PMC 102176. PMID 11094070.

Further reading

Henry RW, Sadowski CL, Kobayashi R, Hernandez N (1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID 7715707. S2CID 4325527.
Yoon JB, Roeder RG (1996). "Cloning of two proximal sequence element-binding transcription factor subunits (gamma and delta) that are required for transcription of small nuclear RNA genes by RNA polymerases II and III and interact with the TATA-binding protein". Mol. Cell. Biol. Advances in Molecular and Cell Biology. 16 (1): 1–9. doi:10.1016/S1569-2558(08)60061-2. ISBN 978-0-7623-0143-0. PMC 230972. PMID 8524284.
Henry RW, Ma B, Sadowski CL, et al. (1997). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. 15 (24): 7129–36. doi:10.1002/j.1460-2075.1996.tb01104.x. PMC 452539. PMID 9003788.
Ma B, Hernandez N (2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
Hirsch HA, Gu L, Henry RW (2001). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. 20 (24): 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. PMC 102176. PMID 11094070.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hinkley CS, Hirsch HA, Gu L, et al. (2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". J. Biol. Chem. 278 (20): 18649–57. doi:10.1074/jbc.M204247200. PMID 12621023.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gu L, Esselman WJ, Henry RW (2005). "Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC". J. Biol. Chem. 280 (30): 27697–704. doi:10.1074/jbc.M503206200. PMID 15955816.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000023608 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021113 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9644240-5] Maeng JH, Yoon JB (September 1998). "The human PTFgamma/SNAP43 gene: structure, chromosomal location, and identification of a VNTR in 5'-UTR". J Biochem. 124 (1): 23–7. doi:10.1093/oxfordjournals.jbchem.a022085. PMID 9644240.

[entrez-6] "Entrez Gene: SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa".

[pmid11056176-7] Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". J. Biol. Chem. 276 (7). United States: 5027–35. doi:10.1074/jbc.M009301200. ISSN 0021-9258. PMID 11056176.

[pmid9003788-8] Henry RW, Ma B, Sadowski C L, Kobayashi R, Hernandez N (Dec 1996). "Cloning and characterization of SNAP50, a subunit of the snRNA-activating protein complex SNAPc". EMBO J. 15 (24). ENGLAND: 7129–36. doi:10.1002/j.1460-2075.1996.tb01104.x. ISSN 0261-4189. PMC 452539. PMID 9003788.

[pmid11094070-9] Hirsch HA, Gu L, Henry R W (Dec 2000). "The Retinoblastoma Tumor Suppressor Protein Targets Distinct General Transcription Factors To Regulate RNA Polymerase III Gene Expression". Mol. Cell. Biol. 20 (24). UNITED STATES: 9182–91. doi:10.1128/MCB.20.24.9182-9191.2000. ISSN 0270-7306. PMC 102176. PMID 11094070.

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